Cargando…
Inter-Subject Correlation in fMRI: Method Validation against Stimulus-Model Based Analysis
Within functional magnetic resonance imaging (fMRI), the use of the traditional general linear model (GLM) based analysis methods is often restricted to strictly controlled research setups requiring a parametric activation model. Instead, Inter-Subject Correlation (ISC) method is based on voxel-wise...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414505/ https://www.ncbi.nlm.nih.gov/pubmed/22924089 http://dx.doi.org/10.1371/journal.pone.0041196 |
_version_ | 1782240221241278464 |
---|---|
author | Pajula, Juha Kauppi, Jukka-Pekka Tohka, Jussi |
author_facet | Pajula, Juha Kauppi, Jukka-Pekka Tohka, Jussi |
author_sort | Pajula, Juha |
collection | PubMed |
description | Within functional magnetic resonance imaging (fMRI), the use of the traditional general linear model (GLM) based analysis methods is often restricted to strictly controlled research setups requiring a parametric activation model. Instead, Inter-Subject Correlation (ISC) method is based on voxel-wise correlation between the time series of the subjects, which makes it completely non-parametric and thus suitable for naturalistic stimulus paradigms such as movie watching. In this study, we compared an ISC based analysis results with those of a GLM based in five distinct controlled research setups. We used International Consortium for Brain Mapping functional reference battery (FRB) fMRI data available from the Laboratory of Neuro Imaging image data archive. The selected data included measurements from 37 right-handed subjects, who all had performed the same five tasks from FRB. The GLM was expected to locate activations accurately in FRB data and thus provide good grounds for investigating relationship between ISC and stimulus induced fMRI activation. The statistical maps of ISC and GLM were compared with two measures. The first measure was the Pearson's correlation between the non-thresholded ISC test-statistics and absolute values of the GLM Z-statistics. The average correlation value over five tasks was 0.74. The second was the Dice index between the activation regions of the methods. The average Dice value over the tasks and three threshold levels was 0.73. The results of this study indicated how the data driven ISC analysis found the same foci as the model-based GLM analysis. The agreement of the results is highly interesting, because ISC is applicable in situations where GLM is not suitable, for example, when analyzing data from a naturalistic stimuli experiment. |
format | Online Article Text |
id | pubmed-3414505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-34145052012-08-24 Inter-Subject Correlation in fMRI: Method Validation against Stimulus-Model Based Analysis Pajula, Juha Kauppi, Jukka-Pekka Tohka, Jussi PLoS One Research Article Within functional magnetic resonance imaging (fMRI), the use of the traditional general linear model (GLM) based analysis methods is often restricted to strictly controlled research setups requiring a parametric activation model. Instead, Inter-Subject Correlation (ISC) method is based on voxel-wise correlation between the time series of the subjects, which makes it completely non-parametric and thus suitable for naturalistic stimulus paradigms such as movie watching. In this study, we compared an ISC based analysis results with those of a GLM based in five distinct controlled research setups. We used International Consortium for Brain Mapping functional reference battery (FRB) fMRI data available from the Laboratory of Neuro Imaging image data archive. The selected data included measurements from 37 right-handed subjects, who all had performed the same five tasks from FRB. The GLM was expected to locate activations accurately in FRB data and thus provide good grounds for investigating relationship between ISC and stimulus induced fMRI activation. The statistical maps of ISC and GLM were compared with two measures. The first measure was the Pearson's correlation between the non-thresholded ISC test-statistics and absolute values of the GLM Z-statistics. The average correlation value over five tasks was 0.74. The second was the Dice index between the activation regions of the methods. The average Dice value over the tasks and three threshold levels was 0.73. The results of this study indicated how the data driven ISC analysis found the same foci as the model-based GLM analysis. The agreement of the results is highly interesting, because ISC is applicable in situations where GLM is not suitable, for example, when analyzing data from a naturalistic stimuli experiment. Public Library of Science 2012-08-08 /pmc/articles/PMC3414505/ /pubmed/22924089 http://dx.doi.org/10.1371/journal.pone.0041196 Text en © 2012 Pajula et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Pajula, Juha Kauppi, Jukka-Pekka Tohka, Jussi Inter-Subject Correlation in fMRI: Method Validation against Stimulus-Model Based Analysis |
title | Inter-Subject Correlation in fMRI: Method Validation against Stimulus-Model Based Analysis |
title_full | Inter-Subject Correlation in fMRI: Method Validation against Stimulus-Model Based Analysis |
title_fullStr | Inter-Subject Correlation in fMRI: Method Validation against Stimulus-Model Based Analysis |
title_full_unstemmed | Inter-Subject Correlation in fMRI: Method Validation against Stimulus-Model Based Analysis |
title_short | Inter-Subject Correlation in fMRI: Method Validation against Stimulus-Model Based Analysis |
title_sort | inter-subject correlation in fmri: method validation against stimulus-model based analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414505/ https://www.ncbi.nlm.nih.gov/pubmed/22924089 http://dx.doi.org/10.1371/journal.pone.0041196 |
work_keys_str_mv | AT pajulajuha intersubjectcorrelationinfmrimethodvalidationagainststimulusmodelbasedanalysis AT kauppijukkapekka intersubjectcorrelationinfmrimethodvalidationagainststimulusmodelbasedanalysis AT tohkajussi intersubjectcorrelationinfmrimethodvalidationagainststimulusmodelbasedanalysis |