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Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome

BACKGROUND: Normal post-squalene cholesterol biosynthesis is important for mammalian embryonic development. Neonatal mice lacking functional dehydrocholesterol Δ7-reductase (Dhcr7), a model for the human disease of Smith-Lemli-Opitz syndrome, die within 24 hours of birth. Although they have a number...

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Detalles Bibliográficos
Autores principales:	Yu, Hongwei, Wessels, Andy, Chen, Jianliang, Phelps, Aimee L, Oatis, John, Tint, G Stephen, Patel, Shailendra B
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2004
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC341451/ https://www.ncbi.nlm.nih.gov/pubmed/15005800 http://dx.doi.org/10.1186/1471-213X-4-1

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