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Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications

Artemisinin-based combination therapies are the most effective drugs to treat Plasmodium falciparum malaria. Reduced sensitivity to artemisinin monotherapy, coupled with the emergence of parasite resistance to all partner drugs, threaten to place millions of patients at risk of inadequate treatment...

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Autores principales: Fairhurst, Rick M., Nayyar, Gaurvika M. L., Breman, Joel G., Hallett, Rachel, Vennerstrom, Jonathan L., Duong, Socheat, Ringwald, Pascal, Wellems, Thomas E., Plowe, Christopher V., Dondorp, Arjen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414557/
https://www.ncbi.nlm.nih.gov/pubmed/22855752
http://dx.doi.org/10.4269/ajtmh.2012.12-0025
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author Fairhurst, Rick M.
Nayyar, Gaurvika M. L.
Breman, Joel G.
Hallett, Rachel
Vennerstrom, Jonathan L.
Duong, Socheat
Ringwald, Pascal
Wellems, Thomas E.
Plowe, Christopher V.
Dondorp, Arjen M.
author_facet Fairhurst, Rick M.
Nayyar, Gaurvika M. L.
Breman, Joel G.
Hallett, Rachel
Vennerstrom, Jonathan L.
Duong, Socheat
Ringwald, Pascal
Wellems, Thomas E.
Plowe, Christopher V.
Dondorp, Arjen M.
author_sort Fairhurst, Rick M.
collection PubMed
description Artemisinin-based combination therapies are the most effective drugs to treat Plasmodium falciparum malaria. Reduced sensitivity to artemisinin monotherapy, coupled with the emergence of parasite resistance to all partner drugs, threaten to place millions of patients at risk of inadequate treatment of malaria. Recognizing the significance and immediacy of this possibility, the Fogarty International Center and the National Institute of Allergy and Infectious Diseases of the U.S. National Institutes of Health convened a conference in November 2010 to bring together the diverse array of stakeholders responding to the growing threat of artemisinin resistance, including scientists from malarious countries in peril. This conference encouraged and enabled experts to share their recent unpublished data from studies that may improve our understanding of artemisinin resistance. Conference sessions addressed research priorities to forestall artemisinin resistance and fostered collaborations between field- and laboratory-based researchers and international programs, with the aim of translating new scientific evidence into public health solutions. Inspired by this conference, this review summarizes novel findings and perspectives on artemisinin resistance, approaches for translating research data into relevant public health information, and opportunities for interdisciplinary collaboration to combat artemisinin resistance.
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spelling pubmed-34145572012-08-13 Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications Fairhurst, Rick M. Nayyar, Gaurvika M. L. Breman, Joel G. Hallett, Rachel Vennerstrom, Jonathan L. Duong, Socheat Ringwald, Pascal Wellems, Thomas E. Plowe, Christopher V. Dondorp, Arjen M. Am J Trop Med Hyg Meeting Report Artemisinin-based combination therapies are the most effective drugs to treat Plasmodium falciparum malaria. Reduced sensitivity to artemisinin monotherapy, coupled with the emergence of parasite resistance to all partner drugs, threaten to place millions of patients at risk of inadequate treatment of malaria. Recognizing the significance and immediacy of this possibility, the Fogarty International Center and the National Institute of Allergy and Infectious Diseases of the U.S. National Institutes of Health convened a conference in November 2010 to bring together the diverse array of stakeholders responding to the growing threat of artemisinin resistance, including scientists from malarious countries in peril. This conference encouraged and enabled experts to share their recent unpublished data from studies that may improve our understanding of artemisinin resistance. Conference sessions addressed research priorities to forestall artemisinin resistance and fostered collaborations between field- and laboratory-based researchers and international programs, with the aim of translating new scientific evidence into public health solutions. Inspired by this conference, this review summarizes novel findings and perspectives on artemisinin resistance, approaches for translating research data into relevant public health information, and opportunities for interdisciplinary collaboration to combat artemisinin resistance. The American Society of Tropical Medicine and Hygiene 2012-08-01 /pmc/articles/PMC3414557/ /pubmed/22855752 http://dx.doi.org/10.4269/ajtmh.2012.12-0025 Text en ©The American Society of Tropical Medicine and Hygiene http://creativecommons.org/licenses/by/2.5/ This is an Open Access article distributed under the terms of the American Society of Tropical Medicine and Hygiene's Re-use License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Meeting Report
Fairhurst, Rick M.
Nayyar, Gaurvika M. L.
Breman, Joel G.
Hallett, Rachel
Vennerstrom, Jonathan L.
Duong, Socheat
Ringwald, Pascal
Wellems, Thomas E.
Plowe, Christopher V.
Dondorp, Arjen M.
Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications
title Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications
title_full Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications
title_fullStr Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications
title_full_unstemmed Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications
title_short Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications
title_sort artemisinin-resistant malaria: research challenges, opportunities, and public health implications
topic Meeting Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414557/
https://www.ncbi.nlm.nih.gov/pubmed/22855752
http://dx.doi.org/10.4269/ajtmh.2012.12-0025
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