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The Rabs: A family at the root of metazoan evolution
Eukaryotic cells are distinguished by their compartmentalization into membrane-enclosed organelles that exchange membranes and content in a highly ordered manner. Central in defining membrane identity are the Rabs, a large family of small GTPases that localize to distinct membranes and recruit speci...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414739/ https://www.ncbi.nlm.nih.gov/pubmed/22873178 http://dx.doi.org/10.1186/1741-7007-10-68 |
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| author | Stenmark, Harald |
| author_facet | Stenmark, Harald |
| author_sort | Stenmark, Harald |
| collection | PubMed |
| description | Eukaryotic cells are distinguished by their compartmentalization into membrane-enclosed organelles that exchange membranes and content in a highly ordered manner. Central in defining membrane identity are the Rabs, a large family of small GTPases that localize to distinct membranes and recruit specific regulators of membrane traffic. Two recent papers, including one by Klöpper et al. in BMC Biology, present phylogenomic evidence that the Rab repertoire was established very early in eukaryotic evolution, and correlates with interspecies variations in organelles. See research article http://www.biomedcentral.com/1741-7007/10/71 |
| format | Online Article Text |
| id | pubmed-3414739 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-34147392012-08-10 The Rabs: A family at the root of metazoan evolution Stenmark, Harald BMC Biol Commentary Eukaryotic cells are distinguished by their compartmentalization into membrane-enclosed organelles that exchange membranes and content in a highly ordered manner. Central in defining membrane identity are the Rabs, a large family of small GTPases that localize to distinct membranes and recruit specific regulators of membrane traffic. Two recent papers, including one by Klöpper et al. in BMC Biology, present phylogenomic evidence that the Rab repertoire was established very early in eukaryotic evolution, and correlates with interspecies variations in organelles. See research article http://www.biomedcentral.com/1741-7007/10/71 BioMed Central 2012-08-08 /pmc/articles/PMC3414739/ /pubmed/22873178 http://dx.doi.org/10.1186/1741-7007-10-68 Text en Copyright ©2012 Stenmark; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Commentary Stenmark, Harald The Rabs: A family at the root of metazoan evolution |
| title | The Rabs: A family at the root of metazoan evolution |
| title_full | The Rabs: A family at the root of metazoan evolution |
| title_fullStr | The Rabs: A family at the root of metazoan evolution |
| title_full_unstemmed | The Rabs: A family at the root of metazoan evolution |
| title_short | The Rabs: A family at the root of metazoan evolution |
| title_sort | rabs: a family at the root of metazoan evolution |
| topic | Commentary |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414739/ https://www.ncbi.nlm.nih.gov/pubmed/22873178 http://dx.doi.org/10.1186/1741-7007-10-68 |
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