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Systemic therapy in the management of metastatic or advanced salivary gland cancers
Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414773/ https://www.ncbi.nlm.nih.gov/pubmed/22558945 http://dx.doi.org/10.1186/1758-3284-4-19 |
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author | Lagha, Aymen Chraiet, Nesrine Ayadi, Mouna Krimi, Sarra Allani, Bassem Rifi, Hela Raies, Henda Mezlini, Amel |
author_facet | Lagha, Aymen Chraiet, Nesrine Ayadi, Mouna Krimi, Sarra Allani, Bassem Rifi, Hela Raies, Henda Mezlini, Amel |
author_sort | Lagha, Aymen |
collection | PubMed |
description | Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports and small studies have investigated the contribution of different agents of chemotherapy. With the extension of molecular biology approach in oncology several signaling pathways have been discovered in different cancers including salivary gland cancers; thus a number of targeted therapies have been investigated. This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers. |
format | Online Article Text |
id | pubmed-3414773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34147732012-08-10 Systemic therapy in the management of metastatic or advanced salivary gland cancers Lagha, Aymen Chraiet, Nesrine Ayadi, Mouna Krimi, Sarra Allani, Bassem Rifi, Hela Raies, Henda Mezlini, Amel Head Neck Oncol Review Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports and small studies have investigated the contribution of different agents of chemotherapy. With the extension of molecular biology approach in oncology several signaling pathways have been discovered in different cancers including salivary gland cancers; thus a number of targeted therapies have been investigated. This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers. BioMed Central 2012-05-04 /pmc/articles/PMC3414773/ /pubmed/22558945 http://dx.doi.org/10.1186/1758-3284-4-19 Text en Copyright © 2012 Lagha et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Lagha, Aymen Chraiet, Nesrine Ayadi, Mouna Krimi, Sarra Allani, Bassem Rifi, Hela Raies, Henda Mezlini, Amel Systemic therapy in the management of metastatic or advanced salivary gland cancers |
title | Systemic therapy in the management of metastatic or advanced salivary gland cancers |
title_full | Systemic therapy in the management of metastatic or advanced salivary gland cancers |
title_fullStr | Systemic therapy in the management of metastatic or advanced salivary gland cancers |
title_full_unstemmed | Systemic therapy in the management of metastatic or advanced salivary gland cancers |
title_short | Systemic therapy in the management of metastatic or advanced salivary gland cancers |
title_sort | systemic therapy in the management of metastatic or advanced salivary gland cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414773/ https://www.ncbi.nlm.nih.gov/pubmed/22558945 http://dx.doi.org/10.1186/1758-3284-4-19 |
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