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Systemic therapy in the management of metastatic or advanced salivary gland cancers

Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports...

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Autores principales: Lagha, Aymen, Chraiet, Nesrine, Ayadi, Mouna, Krimi, Sarra, Allani, Bassem, Rifi, Hela, Raies, Henda, Mezlini, Amel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414773/
https://www.ncbi.nlm.nih.gov/pubmed/22558945
http://dx.doi.org/10.1186/1758-3284-4-19
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author Lagha, Aymen
Chraiet, Nesrine
Ayadi, Mouna
Krimi, Sarra
Allani, Bassem
Rifi, Hela
Raies, Henda
Mezlini, Amel
author_facet Lagha, Aymen
Chraiet, Nesrine
Ayadi, Mouna
Krimi, Sarra
Allani, Bassem
Rifi, Hela
Raies, Henda
Mezlini, Amel
author_sort Lagha, Aymen
collection PubMed
description Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports and small studies have investigated the contribution of different agents of chemotherapy. With the extension of molecular biology approach in oncology several signaling pathways have been discovered in different cancers including salivary gland cancers; thus a number of targeted therapies have been investigated. This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers.
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spelling pubmed-34147732012-08-10 Systemic therapy in the management of metastatic or advanced salivary gland cancers Lagha, Aymen Chraiet, Nesrine Ayadi, Mouna Krimi, Sarra Allani, Bassem Rifi, Hela Raies, Henda Mezlini, Amel Head Neck Oncol Review Salivary gland cancers are very rare tumors. They are characterized by a histologic heterogeneity and a poor outcome. According to this rarity, few prospective data are available to date. No standard recommendations could be held for the use of systemic therapy in these tumors. Several case reports and small studies have investigated the contribution of different agents of chemotherapy. With the extension of molecular biology approach in oncology several signaling pathways have been discovered in different cancers including salivary gland cancers; thus a number of targeted therapies have been investigated. This paper reviewed exhaustively the studies investigating the role of systemic therapies (chemotherapy, targeted therapy, hormone therapy) in salivary gland cancers. BioMed Central 2012-05-04 /pmc/articles/PMC3414773/ /pubmed/22558945 http://dx.doi.org/10.1186/1758-3284-4-19 Text en Copyright © 2012 Lagha et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lagha, Aymen
Chraiet, Nesrine
Ayadi, Mouna
Krimi, Sarra
Allani, Bassem
Rifi, Hela
Raies, Henda
Mezlini, Amel
Systemic therapy in the management of metastatic or advanced salivary gland cancers
title Systemic therapy in the management of metastatic or advanced salivary gland cancers
title_full Systemic therapy in the management of metastatic or advanced salivary gland cancers
title_fullStr Systemic therapy in the management of metastatic or advanced salivary gland cancers
title_full_unstemmed Systemic therapy in the management of metastatic or advanced salivary gland cancers
title_short Systemic therapy in the management of metastatic or advanced salivary gland cancers
title_sort systemic therapy in the management of metastatic or advanced salivary gland cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414773/
https://www.ncbi.nlm.nih.gov/pubmed/22558945
http://dx.doi.org/10.1186/1758-3284-4-19
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