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Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma
OBJECTIVES: Ceruminous adenoma of the external auditory canal (EAC) is a rare type of tumour that is diagnosed histologically. However, the clinical behaviour of these tumours remains controversial. Here, we report a case of ceruminous adenoma of the EAC and expression of a hypoxia marker. CASE REPO...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414790/ https://www.ncbi.nlm.nih.gov/pubmed/22551172 http://dx.doi.org/10.1186/1758-3284-4-18 |
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author | Shen, Wan-Qin Cheng, Ke-Jia Bao, Yang-Yang Zhou, Shui-Hong Yao, Hong-Tian |
author_facet | Shen, Wan-Qin Cheng, Ke-Jia Bao, Yang-Yang Zhou, Shui-Hong Yao, Hong-Tian |
author_sort | Shen, Wan-Qin |
collection | PubMed |
description | OBJECTIVES: Ceruminous adenoma of the external auditory canal (EAC) is a rare type of tumour that is diagnosed histologically. However, the clinical behaviour of these tumours remains controversial. Here, we report a case of ceruminous adenoma of the EAC and expression of a hypoxia marker. CASE REPORT: A 78-year-old man presented with a 6-month history of recurrent otorrhoea in the right ear. Surgery was performed by the transmeatal approach with total removal of the mass. Histopathology revealed a ceruminous adenoma. Tumour cells were positive for CK, S-100 protein, Glut-1, HIF-1α, PI3K and p-Akt. There was no evidence of recurrence at last follow-up 27 months after the operation. CONCLUSIONS: Ceruminous adenoma of the EAC is a rare tumour. The treatment of choice is wide local excision with clear margins. To our knowledge, this is the first report of Glut-1 expression and the PI3K/Akt pathway in ceruminous adenoma of the EAC. |
format | Online Article Text |
id | pubmed-3414790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34147902012-08-10 Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma Shen, Wan-Qin Cheng, Ke-Jia Bao, Yang-Yang Zhou, Shui-Hong Yao, Hong-Tian Head Neck Oncol Case Report OBJECTIVES: Ceruminous adenoma of the external auditory canal (EAC) is a rare type of tumour that is diagnosed histologically. However, the clinical behaviour of these tumours remains controversial. Here, we report a case of ceruminous adenoma of the EAC and expression of a hypoxia marker. CASE REPORT: A 78-year-old man presented with a 6-month history of recurrent otorrhoea in the right ear. Surgery was performed by the transmeatal approach with total removal of the mass. Histopathology revealed a ceruminous adenoma. Tumour cells were positive for CK, S-100 protein, Glut-1, HIF-1α, PI3K and p-Akt. There was no evidence of recurrence at last follow-up 27 months after the operation. CONCLUSIONS: Ceruminous adenoma of the EAC is a rare tumour. The treatment of choice is wide local excision with clear margins. To our knowledge, this is the first report of Glut-1 expression and the PI3K/Akt pathway in ceruminous adenoma of the EAC. BioMed Central 2012-05-02 /pmc/articles/PMC3414790/ /pubmed/22551172 http://dx.doi.org/10.1186/1758-3284-4-18 Text en Copyright © 2012 Shen et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Shen, Wan-Qin Cheng, Ke-Jia Bao, Yang-Yang Zhou, Shui-Hong Yao, Hong-Tian Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma |
title | Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma |
title_full | Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma |
title_fullStr | Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma |
title_full_unstemmed | Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma |
title_short | Expression of Glut-1, HIF-1α, PI3K and p-Akt in a case of ceruminous adenoma |
title_sort | expression of glut-1, hif-1α, pi3k and p-akt in a case of ceruminous adenoma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414790/ https://www.ncbi.nlm.nih.gov/pubmed/22551172 http://dx.doi.org/10.1186/1758-3284-4-18 |
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