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How do alignment programs perform on sequencing data with varying qualities and from repetitive regions?
BACKGROUND: Next-generation sequencing technologies generate a significant number of short reads that are utilized to address a variety of biological questions. However, quite often, sequencing reads tend to have low quality at the 3’ end and are generated from the repetitive regions of a genome. It...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3414812/ https://www.ncbi.nlm.nih.gov/pubmed/22709551 http://dx.doi.org/10.1186/1756-0381-5-6 |