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The Redox System in C. elegans, a Phylogenetic Approach

Oxidative stress is a toxic state caused by an imbalance between the production and elimination of reactive oxygen species (ROS). ROS cause oxidative damage to cellular components such as proteins, lipids, and nucleic acids. While the role of ROS in cellular damage is frequently all that is noted, R...

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Autores principales: Johnston, Andrew D., Ebert, Paul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415087/
https://www.ncbi.nlm.nih.gov/pubmed/22899914
http://dx.doi.org/10.1155/2012/546915
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author Johnston, Andrew D.
Ebert, Paul R.
author_facet Johnston, Andrew D.
Ebert, Paul R.
author_sort Johnston, Andrew D.
collection PubMed
description Oxidative stress is a toxic state caused by an imbalance between the production and elimination of reactive oxygen species (ROS). ROS cause oxidative damage to cellular components such as proteins, lipids, and nucleic acids. While the role of ROS in cellular damage is frequently all that is noted, ROS are also important in redox signalling. The “Redox Hypothesis" has been proposed to emphasize a dual role of ROS. This hypothesis suggests that the primary effect of changes to the redox state is modified cellular signalling rather than simply oxidative damage. In extreme cases, alteration of redox signalling can contribute to the toxicity of ROS, as well as to ageing and age-related diseases. The nematode species Caenorhabditis elegans provides an excellent model for the study of oxidative stress and redox signalling in animals. We use protein sequences from central redox systems in Homo sapiens, Drosophila melanogaster, and Saccharomyces cerevisiae to query Genbank for homologous proteins in C. elegans. We then use maximum likelihood phylogenetic analysis to compare protein families between C. elegans and the other organisms to facilitate future research into the genetics of redox biology.
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spelling pubmed-34150872012-08-16 The Redox System in C. elegans, a Phylogenetic Approach Johnston, Andrew D. Ebert, Paul R. J Toxicol Review Article Oxidative stress is a toxic state caused by an imbalance between the production and elimination of reactive oxygen species (ROS). ROS cause oxidative damage to cellular components such as proteins, lipids, and nucleic acids. While the role of ROS in cellular damage is frequently all that is noted, ROS are also important in redox signalling. The “Redox Hypothesis" has been proposed to emphasize a dual role of ROS. This hypothesis suggests that the primary effect of changes to the redox state is modified cellular signalling rather than simply oxidative damage. In extreme cases, alteration of redox signalling can contribute to the toxicity of ROS, as well as to ageing and age-related diseases. The nematode species Caenorhabditis elegans provides an excellent model for the study of oxidative stress and redox signalling in animals. We use protein sequences from central redox systems in Homo sapiens, Drosophila melanogaster, and Saccharomyces cerevisiae to query Genbank for homologous proteins in C. elegans. We then use maximum likelihood phylogenetic analysis to compare protein families between C. elegans and the other organisms to facilitate future research into the genetics of redox biology. Hindawi Publishing Corporation 2012 2012-07-31 /pmc/articles/PMC3415087/ /pubmed/22899914 http://dx.doi.org/10.1155/2012/546915 Text en Copyright © 2012 A. D. Johnston and P. R. Ebert. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Johnston, Andrew D.
Ebert, Paul R.
The Redox System in C. elegans, a Phylogenetic Approach
title The Redox System in C. elegans, a Phylogenetic Approach
title_full The Redox System in C. elegans, a Phylogenetic Approach
title_fullStr The Redox System in C. elegans, a Phylogenetic Approach
title_full_unstemmed The Redox System in C. elegans, a Phylogenetic Approach
title_short The Redox System in C. elegans, a Phylogenetic Approach
title_sort redox system in c. elegans, a phylogenetic approach
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415087/
https://www.ncbi.nlm.nih.gov/pubmed/22899914
http://dx.doi.org/10.1155/2012/546915
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