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Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin
This study is aimed to investigate the Aconitum Lizhong pill (ALZ) pharmacological actions on hypothermia with indigestion, especially the ghrelin roles. The littermate-matched rats were randomly divided into four groups. Control did sham operation or standard diet, Model carried out interscapular b...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415136/ https://www.ncbi.nlm.nih.gov/pubmed/22899955 http://dx.doi.org/10.1155/2012/542461 |
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author | Zhao, Xin Wang, Yong Yang, Shijun Zhang, Wentong Zu, Chengzhe Zhang, Taotao Tang, Binghua Zhang, Baochun Li, Guozhang Deng, Bo Cai, Dayong |
author_facet | Zhao, Xin Wang, Yong Yang, Shijun Zhang, Wentong Zu, Chengzhe Zhang, Taotao Tang, Binghua Zhang, Baochun Li, Guozhang Deng, Bo Cai, Dayong |
author_sort | Zhao, Xin |
collection | PubMed |
description | This study is aimed to investigate the Aconitum Lizhong pill (ALZ) pharmacological actions on hypothermia with indigestion, especially the ghrelin roles. The littermate-matched rats were randomly divided into four groups. Control did sham operation or standard diet, Model carried out interscapular brown adipose (IBA) removal with standard diet, Fat-diet did IBA removal with fat-diet, and ALZ did IBA removal and fat-diet with 4.536 g/kg/d ALZ. The potency of adaptive thermogenesis, ghrelin levels in plasma or gastric mucosa, thyroid hormones and metabolite in sera, expression of ghrelin mRNA, and protein in gastric mucous membrane were determined. ALZ relieved the hypothermia processes with indigestion, via inhibiting ghrelin expression and increasing ghrelin secretion; the dynamics from the therapy is supported with the energy changes as less body weight loss, less plasma lipid decrease, more plasma T (3) or T (4) increase with TSH decrease, and more compensation of thermogenic AUC decrease. Ghrelin played key roles in the actions of ALZ on the hypothermia with indigestion. The pharmacological mechanisms of ALZ involved the homeostasis of ghrelin expression and secretion. |
format | Online Article Text |
id | pubmed-3415136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34151362012-08-16 Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin Zhao, Xin Wang, Yong Yang, Shijun Zhang, Wentong Zu, Chengzhe Zhang, Taotao Tang, Binghua Zhang, Baochun Li, Guozhang Deng, Bo Cai, Dayong Evid Based Complement Alternat Med Research Article This study is aimed to investigate the Aconitum Lizhong pill (ALZ) pharmacological actions on hypothermia with indigestion, especially the ghrelin roles. The littermate-matched rats were randomly divided into four groups. Control did sham operation or standard diet, Model carried out interscapular brown adipose (IBA) removal with standard diet, Fat-diet did IBA removal with fat-diet, and ALZ did IBA removal and fat-diet with 4.536 g/kg/d ALZ. The potency of adaptive thermogenesis, ghrelin levels in plasma or gastric mucosa, thyroid hormones and metabolite in sera, expression of ghrelin mRNA, and protein in gastric mucous membrane were determined. ALZ relieved the hypothermia processes with indigestion, via inhibiting ghrelin expression and increasing ghrelin secretion; the dynamics from the therapy is supported with the energy changes as less body weight loss, less plasma lipid decrease, more plasma T (3) or T (4) increase with TSH decrease, and more compensation of thermogenic AUC decrease. Ghrelin played key roles in the actions of ALZ on the hypothermia with indigestion. The pharmacological mechanisms of ALZ involved the homeostasis of ghrelin expression and secretion. Hindawi Publishing Corporation 2012 2012-07-31 /pmc/articles/PMC3415136/ /pubmed/22899955 http://dx.doi.org/10.1155/2012/542461 Text en Copyright © 2012 Xin Zhao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhao, Xin Wang, Yong Yang, Shijun Zhang, Wentong Zu, Chengzhe Zhang, Taotao Tang, Binghua Zhang, Baochun Li, Guozhang Deng, Bo Cai, Dayong Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin |
title | Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin |
title_full | Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin |
title_fullStr | Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin |
title_full_unstemmed | Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin |
title_short | Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin |
title_sort | underlying mechanism of aconitum lizhong acting on experimental hypothermia with indigestion in rats: role of ghrelin |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415136/ https://www.ncbi.nlm.nih.gov/pubmed/22899955 http://dx.doi.org/10.1155/2012/542461 |
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