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Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin

This study is aimed to investigate the Aconitum Lizhong pill (ALZ) pharmacological actions on hypothermia with indigestion, especially the ghrelin roles. The littermate-matched rats were randomly divided into four groups. Control did sham operation or standard diet, Model carried out interscapular b...

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Autores principales: Zhao, Xin, Wang, Yong, Yang, Shijun, Zhang, Wentong, Zu, Chengzhe, Zhang, Taotao, Tang, Binghua, Zhang, Baochun, Li, Guozhang, Deng, Bo, Cai, Dayong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415136/
https://www.ncbi.nlm.nih.gov/pubmed/22899955
http://dx.doi.org/10.1155/2012/542461
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author Zhao, Xin
Wang, Yong
Yang, Shijun
Zhang, Wentong
Zu, Chengzhe
Zhang, Taotao
Tang, Binghua
Zhang, Baochun
Li, Guozhang
Deng, Bo
Cai, Dayong
author_facet Zhao, Xin
Wang, Yong
Yang, Shijun
Zhang, Wentong
Zu, Chengzhe
Zhang, Taotao
Tang, Binghua
Zhang, Baochun
Li, Guozhang
Deng, Bo
Cai, Dayong
author_sort Zhao, Xin
collection PubMed
description This study is aimed to investigate the Aconitum Lizhong pill (ALZ) pharmacological actions on hypothermia with indigestion, especially the ghrelin roles. The littermate-matched rats were randomly divided into four groups. Control did sham operation or standard diet, Model carried out interscapular brown adipose (IBA) removal with standard diet, Fat-diet did IBA removal with fat-diet, and ALZ did IBA removal and fat-diet with 4.536 g/kg/d ALZ. The potency of adaptive thermogenesis, ghrelin levels in plasma or gastric mucosa, thyroid hormones and metabolite in sera, expression of ghrelin mRNA, and protein in gastric mucous membrane were determined. ALZ relieved the hypothermia processes with indigestion, via inhibiting ghrelin expression and increasing ghrelin secretion; the dynamics from the therapy is supported with the energy changes as less body weight loss, less plasma lipid decrease, more plasma T (3) or T (4) increase with TSH decrease, and more compensation of thermogenic AUC decrease. Ghrelin played key roles in the actions of ALZ on the hypothermia with indigestion. The pharmacological mechanisms of ALZ involved the homeostasis of ghrelin expression and secretion.
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spelling pubmed-34151362012-08-16 Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin Zhao, Xin Wang, Yong Yang, Shijun Zhang, Wentong Zu, Chengzhe Zhang, Taotao Tang, Binghua Zhang, Baochun Li, Guozhang Deng, Bo Cai, Dayong Evid Based Complement Alternat Med Research Article This study is aimed to investigate the Aconitum Lizhong pill (ALZ) pharmacological actions on hypothermia with indigestion, especially the ghrelin roles. The littermate-matched rats were randomly divided into four groups. Control did sham operation or standard diet, Model carried out interscapular brown adipose (IBA) removal with standard diet, Fat-diet did IBA removal with fat-diet, and ALZ did IBA removal and fat-diet with 4.536 g/kg/d ALZ. The potency of adaptive thermogenesis, ghrelin levels in plasma or gastric mucosa, thyroid hormones and metabolite in sera, expression of ghrelin mRNA, and protein in gastric mucous membrane were determined. ALZ relieved the hypothermia processes with indigestion, via inhibiting ghrelin expression and increasing ghrelin secretion; the dynamics from the therapy is supported with the energy changes as less body weight loss, less plasma lipid decrease, more plasma T (3) or T (4) increase with TSH decrease, and more compensation of thermogenic AUC decrease. Ghrelin played key roles in the actions of ALZ on the hypothermia with indigestion. The pharmacological mechanisms of ALZ involved the homeostasis of ghrelin expression and secretion. Hindawi Publishing Corporation 2012 2012-07-31 /pmc/articles/PMC3415136/ /pubmed/22899955 http://dx.doi.org/10.1155/2012/542461 Text en Copyright © 2012 Xin Zhao et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhao, Xin
Wang, Yong
Yang, Shijun
Zhang, Wentong
Zu, Chengzhe
Zhang, Taotao
Tang, Binghua
Zhang, Baochun
Li, Guozhang
Deng, Bo
Cai, Dayong
Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin
title Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin
title_full Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin
title_fullStr Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin
title_full_unstemmed Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin
title_short Underlying Mechanism of Aconitum Lizhong Acting on Experimental Hypothermia with Indigestion in Rats: Role of Ghrelin
title_sort underlying mechanism of aconitum lizhong acting on experimental hypothermia with indigestion in rats: role of ghrelin
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415136/
https://www.ncbi.nlm.nih.gov/pubmed/22899955
http://dx.doi.org/10.1155/2012/542461
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