Administration of Recombinant Heat Shock Protein 70 Delays Peripheral Muscle Denervation in the SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis

A prominent clinical feature of ALS is muscle weakness due to dysfunction, denervation and degeneration of motoneurons (MNs). While MN degeneration is a late stage event in the ALS mouse model, muscle denervation occurs significantly earlier in the disease. Strategies to prevent this early denervati...

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Detalles Bibliográficos
Autores principales: Gifondorwa, David J., Jimenz-Moreno, Ramon, Hayes, Crystal D., Rouhani, Hesam, Robinson, Mac B., Strupe, Jane L., Caress, James, Milligan, Carol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415202/
https://www.ncbi.nlm.nih.gov/pubmed/22900172
http://dx.doi.org/10.1155/2012/170426

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