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Interocular Asymmetry of Foveal Thickness in Parkinson Disease
Purpose. To quantify interocular asymmetry (IA) of foveal thickness in Parkinson disease (PD) versus that of controls. Design. Prospective case-control series. Methods. In vivo assessment of foveal thickness of 46 eyes of 23 PD patients and 36 eyes of 18 control subjects was studied using spectral d...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415246/ https://www.ncbi.nlm.nih.gov/pubmed/22900149 http://dx.doi.org/10.1155/2012/728457 |
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author | Shrier, Eric M. Adam, Christopher R. Spund, Brian Glazman, Sofya Bodis-Wollner, Ivan |
author_facet | Shrier, Eric M. Adam, Christopher R. Spund, Brian Glazman, Sofya Bodis-Wollner, Ivan |
author_sort | Shrier, Eric M. |
collection | PubMed |
description | Purpose. To quantify interocular asymmetry (IA) of foveal thickness in Parkinson disease (PD) versus that of controls. Design. Prospective case-control series. Methods. In vivo assessment of foveal thickness of 46 eyes of 23 PD patients and 36 eyes of 18 control subjects was studied using spectral domain optical coherence tomography (SD-OCT). Inner versus outer layer retinal segmentation and macular volumes were quantified using the manufacturer's software, while foveal thickness was measured using the raw data from each eye in a grid covering a 6 by 6 mm area centered on the foveola in 0.25 mm steps. Thickness data were entered into MATLAB software. Results. Macular volumes differed significantly at the largest (Zone 3) diameter centered on the foveola (ETDRS protocol). By segmenting inner from outer layers, we found that the IA in PD is mostly due to changes on the slope of the foveal pit at the radial distances of 0.5 and 0.75 mm (1.5 mm and 1 mm diameter). Conclusions. About half of the PD patients had IA of the slope of the foveal pit. IA is a potentially useful marker of PD and is expected to be comparable across different SD-OCT equipment. Data of larger groups may be developed in future multicenter studies. |
format | Online Article Text |
id | pubmed-3415246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34152462012-08-16 Interocular Asymmetry of Foveal Thickness in Parkinson Disease Shrier, Eric M. Adam, Christopher R. Spund, Brian Glazman, Sofya Bodis-Wollner, Ivan J Ophthalmol Research Article Purpose. To quantify interocular asymmetry (IA) of foveal thickness in Parkinson disease (PD) versus that of controls. Design. Prospective case-control series. Methods. In vivo assessment of foveal thickness of 46 eyes of 23 PD patients and 36 eyes of 18 control subjects was studied using spectral domain optical coherence tomography (SD-OCT). Inner versus outer layer retinal segmentation and macular volumes were quantified using the manufacturer's software, while foveal thickness was measured using the raw data from each eye in a grid covering a 6 by 6 mm area centered on the foveola in 0.25 mm steps. Thickness data were entered into MATLAB software. Results. Macular volumes differed significantly at the largest (Zone 3) diameter centered on the foveola (ETDRS protocol). By segmenting inner from outer layers, we found that the IA in PD is mostly due to changes on the slope of the foveal pit at the radial distances of 0.5 and 0.75 mm (1.5 mm and 1 mm diameter). Conclusions. About half of the PD patients had IA of the slope of the foveal pit. IA is a potentially useful marker of PD and is expected to be comparable across different SD-OCT equipment. Data of larger groups may be developed in future multicenter studies. Hindawi Publishing Corporation 2012 2012-08-01 /pmc/articles/PMC3415246/ /pubmed/22900149 http://dx.doi.org/10.1155/2012/728457 Text en Copyright © 2012 Eric M. Shrier et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Shrier, Eric M. Adam, Christopher R. Spund, Brian Glazman, Sofya Bodis-Wollner, Ivan Interocular Asymmetry of Foveal Thickness in Parkinson Disease |
title | Interocular Asymmetry of Foveal Thickness in Parkinson Disease |
title_full | Interocular Asymmetry of Foveal Thickness in Parkinson Disease |
title_fullStr | Interocular Asymmetry of Foveal Thickness in Parkinson Disease |
title_full_unstemmed | Interocular Asymmetry of Foveal Thickness in Parkinson Disease |
title_short | Interocular Asymmetry of Foveal Thickness in Parkinson Disease |
title_sort | interocular asymmetry of foveal thickness in parkinson disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415246/ https://www.ncbi.nlm.nih.gov/pubmed/22900149 http://dx.doi.org/10.1155/2012/728457 |
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