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The Suckling Rat as a Model for Immunonutrition Studies in Early Life

Diet plays a crucial role in maintaining optimal immune function. Research demonstrates the immunomodulatory properties and mechanisms of particular nutrients; however, these aspects are studied less in early life, when diet may exert an important role in the immune development of the neonate. Besid...

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Autores principales: Pérez-Cano, Francisco J., Franch, Àngels, Castellote, Cristina, Castell, Margarida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415261/
https://www.ncbi.nlm.nih.gov/pubmed/22899949
http://dx.doi.org/10.1155/2012/537310
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author Pérez-Cano, Francisco J.
Franch, Àngels
Castellote, Cristina
Castell, Margarida
author_facet Pérez-Cano, Francisco J.
Franch, Àngels
Castellote, Cristina
Castell, Margarida
author_sort Pérez-Cano, Francisco J.
collection PubMed
description Diet plays a crucial role in maintaining optimal immune function. Research demonstrates the immunomodulatory properties and mechanisms of particular nutrients; however, these aspects are studied less in early life, when diet may exert an important role in the immune development of the neonate. Besides the limited data from epidemiological and human interventional trials in early life, animal models hold the key to increase the current knowledge about this interaction in this particular period. This paper reports the potential of the suckling rat as a model for immunonutrition studies in early life. In particular, it describes the main changes in the systemic and mucosal immune system development during rat suckling and allows some of these elements to be established as target biomarkers for studying the influence of particular nutrients. Different approaches to evaluate these immune effects, including the manipulation of the maternal diet during gestation and/or lactation or feeding the nutrient directly to the pups, are also described in detail. In summary, this paper provides investigators with useful tools for better designing experimental approaches focused on nutrition in early life for programming and immune development by using the suckling rat as a model.
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spelling pubmed-34152612012-08-16 The Suckling Rat as a Model for Immunonutrition Studies in Early Life Pérez-Cano, Francisco J. Franch, Àngels Castellote, Cristina Castell, Margarida Clin Dev Immunol Review Article Diet plays a crucial role in maintaining optimal immune function. Research demonstrates the immunomodulatory properties and mechanisms of particular nutrients; however, these aspects are studied less in early life, when diet may exert an important role in the immune development of the neonate. Besides the limited data from epidemiological and human interventional trials in early life, animal models hold the key to increase the current knowledge about this interaction in this particular period. This paper reports the potential of the suckling rat as a model for immunonutrition studies in early life. In particular, it describes the main changes in the systemic and mucosal immune system development during rat suckling and allows some of these elements to be established as target biomarkers for studying the influence of particular nutrients. Different approaches to evaluate these immune effects, including the manipulation of the maternal diet during gestation and/or lactation or feeding the nutrient directly to the pups, are also described in detail. In summary, this paper provides investigators with useful tools for better designing experimental approaches focused on nutrition in early life for programming and immune development by using the suckling rat as a model. Hindawi Publishing Corporation 2012 2012-07-31 /pmc/articles/PMC3415261/ /pubmed/22899949 http://dx.doi.org/10.1155/2012/537310 Text en Copyright © 2012 Francisco J. Pérez-Cano et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Pérez-Cano, Francisco J.
Franch, Àngels
Castellote, Cristina
Castell, Margarida
The Suckling Rat as a Model for Immunonutrition Studies in Early Life
title The Suckling Rat as a Model for Immunonutrition Studies in Early Life
title_full The Suckling Rat as a Model for Immunonutrition Studies in Early Life
title_fullStr The Suckling Rat as a Model for Immunonutrition Studies in Early Life
title_full_unstemmed The Suckling Rat as a Model for Immunonutrition Studies in Early Life
title_short The Suckling Rat as a Model for Immunonutrition Studies in Early Life
title_sort suckling rat as a model for immunonutrition studies in early life
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415261/
https://www.ncbi.nlm.nih.gov/pubmed/22899949
http://dx.doi.org/10.1155/2012/537310
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