Cargando…

Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications

Hematological malignancies treatment improved over the last years resulting in increased achievement of complete or partial remission, but unfortunately high relapse rates are still observed. Therefore, sustainment of long-term remission is crucial. Immune system has a key role in tumor surveillance...

Descripción completa

Detalles Bibliográficos
Autores principales: Farnault, Laure, Sanchez, Carole, Baier, Céline, Le Treut, Thérèse, Costello, Régis T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415262/
https://www.ncbi.nlm.nih.gov/pubmed/22899948
http://dx.doi.org/10.1155/2012/421702
_version_ 1782240343541940224
author Farnault, Laure
Sanchez, Carole
Baier, Céline
Le Treut, Thérèse
Costello, Régis T.
author_facet Farnault, Laure
Sanchez, Carole
Baier, Céline
Le Treut, Thérèse
Costello, Régis T.
author_sort Farnault, Laure
collection PubMed
description Hematological malignancies treatment improved over the last years resulting in increased achievement of complete or partial remission, but unfortunately high relapse rates are still observed. Therefore, sustainment of long-term remission is crucial. Immune system has a key role in tumor surveillance. Natural killer (NK) cells, at the frontier of innate and adaptive immune system, have a central role in tumor cells surveillance as demonstrated in the setting of allogenic stem cell transplantation. Nevertheless, tumor cells develop various mechanisms to escape from NK cells innate immune pressure. Abnormal NK cytolytic functions have been described in nearly all hematological malignancies. We present here various mechanisms involved in the escape of hematological malignancies from NK cells surveillance: NK cells quantitative deficiency and NK cell qualitative deficiency by increased inhibition signaling or decreased activating stimuli. A challenge of immunotherapy is to restore an efficient antitumor response. A combination of classical therapy plus immune modulation strategies will soon become a standard of care for hematological malignancies.
format Online
Article
Text
id pubmed-3415262
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-34152622012-08-16 Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications Farnault, Laure Sanchez, Carole Baier, Céline Le Treut, Thérèse Costello, Régis T. Clin Dev Immunol Review Article Hematological malignancies treatment improved over the last years resulting in increased achievement of complete or partial remission, but unfortunately high relapse rates are still observed. Therefore, sustainment of long-term remission is crucial. Immune system has a key role in tumor surveillance. Natural killer (NK) cells, at the frontier of innate and adaptive immune system, have a central role in tumor cells surveillance as demonstrated in the setting of allogenic stem cell transplantation. Nevertheless, tumor cells develop various mechanisms to escape from NK cells innate immune pressure. Abnormal NK cytolytic functions have been described in nearly all hematological malignancies. We present here various mechanisms involved in the escape of hematological malignancies from NK cells surveillance: NK cells quantitative deficiency and NK cell qualitative deficiency by increased inhibition signaling or decreased activating stimuli. A challenge of immunotherapy is to restore an efficient antitumor response. A combination of classical therapy plus immune modulation strategies will soon become a standard of care for hematological malignancies. Hindawi Publishing Corporation 2012 2012-08-01 /pmc/articles/PMC3415262/ /pubmed/22899948 http://dx.doi.org/10.1155/2012/421702 Text en Copyright © 2012 Laure Farnault et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Farnault, Laure
Sanchez, Carole
Baier, Céline
Le Treut, Thérèse
Costello, Régis T.
Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications
title Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications
title_full Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications
title_fullStr Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications
title_full_unstemmed Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications
title_short Hematological Malignancies Escape from NK Cell Innate Immune Surveillance: Mechanisms and Therapeutic Implications
title_sort hematological malignancies escape from nk cell innate immune surveillance: mechanisms and therapeutic implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415262/
https://www.ncbi.nlm.nih.gov/pubmed/22899948
http://dx.doi.org/10.1155/2012/421702
work_keys_str_mv AT farnaultlaure hematologicalmalignanciesescapefromnkcellinnateimmunesurveillancemechanismsandtherapeuticimplications
AT sanchezcarole hematologicalmalignanciesescapefromnkcellinnateimmunesurveillancemechanismsandtherapeuticimplications
AT baierceline hematologicalmalignanciesescapefromnkcellinnateimmunesurveillancemechanismsandtherapeuticimplications
AT letreuttherese hematologicalmalignanciesescapefromnkcellinnateimmunesurveillancemechanismsandtherapeuticimplications
AT costelloregist hematologicalmalignanciesescapefromnkcellinnateimmunesurveillancemechanismsandtherapeuticimplications