Cardiac-Specific Over-Expression of Epidermal Growth Factor Receptor 2 (ErbB2) Induces Pro-Survival Pathways and Hypertrophic Cardiomyopathy in Mice

BACKGROUND: Emerging evidence shows that ErbB2 signaling has a critical role in cardiomyocyte physiology, based mainly on findings that blocking ErbB2 for cancer therapy is toxic to cardiac cells. However, consequences of high levels of ErbB2 activity in the heart have not been previously explored....

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Detalles Bibliográficos
Autores principales: Sysa-Shah, Polina, Xu, Yi, Guo, Xin, Belmonte, Frances, Kang, Byunghak, Bedja, Djahida, Pin, Scott, Tsuchiya, Noriko, Gabrielson, Kathleen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415416/
https://www.ncbi.nlm.nih.gov/pubmed/22912742
http://dx.doi.org/10.1371/journal.pone.0042805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415416/
https://www.ncbi.nlm.nih.gov/pubmed/22912742
http://dx.doi.org/10.1371/journal.pone.0042805

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