Cargando…

Fine-Mapping and Initial Characterization of QT Interval Loci in African Americans

The QT interval (QT) is heritable and its prolongation is a risk factor for ventricular tachyarrhythmias and sudden death. Most genetic studies of QT have examined European ancestral populations; however, the increased genetic diversity in African Americans provides opportunities to narrow associati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Avery, Christy L., Sethupathy, Praveen, Buyske, Steven, He, Qianchuan, Lin, Dan-Yu, Arking, Dan E., Carty, Cara L., Duggan, David, Fesinmeyer, Megan D., Hindorff, Lucia A., Jeff, Janina M., Klein, Liviu, Patton, Kristen K., Peters, Ulrike, Shohet, Ralph V., Sotoodehnia, Nona, Young, Alicia M., Kooperberg, Charles, Haiman, Christopher A., Mohlke, Karen L., Whitsel, Eric A., North, Kari E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415454/ https://www.ncbi.nlm.nih.gov/pubmed/22912591 http://dx.doi.org/10.1371/journal.pgen.1002870

Ejemplares similares

Outcome by Sex in Patients With Long QT Syndrome With an Implantable Cardioverter Defibrillator
por: Younis, Arwa, et al.
Publicado: (2020)

Generalization and Dilution of Association Results from European GWAS in Populations of Non-European Ancestry: The PAGE Study
por: Carlson, Christopher S., et al.
Publicado: (2013)

Genetic variant annotation scores in congenital long QT syndrome
por: Younis, Arwa, et al.
Publicado: (2023)

Effect of Sex and Underlying Disease on the Genetic Association of QT Interval and Sudden Cardiac Death
por: Mitchell, Rebecca N., et al.
Publicado: (2019)

Risk Prediction in Women With Congenital Long QT Syndrome
por: Goldenberg, Ilan, et al.
Publicado: (2021)

GWAS of the electrocardiographic QT interval in Hispanics/Latinos generalizes previously identified loci and identifies population-specific signals
por: Méndez-Giráldez, Raúl, et al.
Publicado: (2017)

Evaluation of the Metabochip Genotyping Array in African Americans and Implications for Fine Mapping of GWAS-Identified Loci: The PAGE Study
por: Buyske, Steven, et al.
Publicado: (2012)

A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans
por: Pendergrass, Sarah A., et al.
Publicado: (2019)

The Next PAGE in Understanding Complex Traits: Design for the Analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study
por: Matise, Tara C., et al.
Publicado: (2011)

Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study
por: Taylor, Kira C, et al.
Publicado: (2013)

A Phenomics-Based Strategy Identifies Loci on APOC1, BRAP, and PLCG1 Associated with Metabolic Syndrome Phenotype Domains
por: Avery, Christy L., et al.
Publicado: (2011)

Rare coding TTN variants are associated with electrocardiographic QT interval in the general population
por: Kapoor, Ashish, et al.
Publicado: (2016)

A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study
por: Peters, Ulrike, et al.
Publicado: (2013)

Genome-wide Association Study of Susceptibility to Particulate Matter–Associated QT Prolongation
por: Gondalia, Rahul, et al.
Publicado: (2017)

Erratum: “Genome-wide Association Study of Susceptibility to Particulate Matter-Associated QT Prolongation”
por: Gondalia, Rahul, et al.
Publicado: (2017)

Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study
por: Dumitrescu, Logan, et al.
Publicado: (2011)

Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network
por: Pendergrass, Sarah A., et al.
Publicado: (2013)

Pleiotropy of Cancer Susceptibility Variants on the Risk of Non-Hodgkin Lymphoma: The PAGE Consortium
por: Lim, Unhee, et al.
Publicado: (2014)

Multiple Independent Genetic Factors at NOS1AP Modulate the QT Interval in a Multi-Ethnic Population
por: Arking, Dan E., et al.
Publicado: (2009)

Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval
por: Avery, Christy L., et al.
Publicado: (2013)

Genetic risk factors for body mass index and obesity in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) Study
por: Fesinmeyer, MD, et al.
Publicado: (2013)

Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics
por: Hodonsky, Chani J., et al.
Publicado: (2020)

Electrocardiographic Deep Terminal Negativity of the P Wave in V(1) and Risk of Sudden Cardiac Death: The Atherosclerosis Risk in Communities (ARIC) Study
por: Tereshchenko, Larisa G., et al.
Publicado: (2014)

MUSSEL: Enhanced Bayesian Polygenic Risk Prediction Leveraging Information across Multiple Ancestry Groups
por: Jin, Jin, et al.
Publicado: (2023)

Prospective Associations of Coronary Heart Disease Loci in African Americans Using the MetaboChip: The PAGE Study
por: Franceschini, Nora, et al.
Publicado: (2014)

Development and optimization of an in vivo electrocardiogram recording method and analysis program for adult zebrafish
por: Duong, ThuyVy, et al.
Publicado: (2021)

Genetic Variation and Reproductive Timing: African American Women from the Population Architecture Using Genomics and Epidemiology (PAGE) Study
por: Spencer, Kylee L., et al.
Publicado: (2013)

Strategies for Enriching Variant Coverage in Candidate Disease Loci on a Multiethnic Genotyping Array
por: Bien, Stephanie A., et al.
Publicado: (2016)

Beat‐to‐Beat Spatiotemporal Variability in the T Vector Is Associated With Sudden Cardiac Death in Participants Without Left Ventricular Hypertrophy: The Atherosclerosis Risk in Communities (ARIC) Study
por: Waks, Jonathan W., et al.
Publicado: (2015)

Large-scale pharmacogenomic study of sulfonylureas and the QT, JT, and QRS intervals: CHARGE Pharmacogenomics Working Group
por: Floyd, James S, et al.
Publicado: (2016)

Variant Discovery and Fine Mapping of Genetic Loci Associated with Blood Pressure Traits in Hispanics and African Americans
por: Franceschini, Nora, et al.
Publicado: (2016)

QT interval and arrhythmic safety of hydroxychloroquine monotherapy in coronavirus disease 2019
por: Sridhar, Arun R., et al.
Publicado: (2020)

HNF1B and Endometrial Cancer Risk: Results from the PAGE study
por: Setiawan, Veronica Wendy, et al.
Publicado: (2012)

QT Adaptation and Intrinsic QT Variability in Congenital Long QT Syndrome
por: Seethala, Srikanth, et al.
Publicado: (2015)

Manual vs. automatic assessment of the QT-interval and corrected QT
por: Neumann, Benjamin, et al.
Publicado: (2023)

QT interval variations and mortality risk: Is there any relationship?
por: Rezuş, Ciprian, et al.
Publicado: (2015)

Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium
por: Haiman, Christopher A., et al.
Publicado: (2012)

Genetic variants associated with fasting glucose and insulin concentrations in an ethnically diverse population: results from the Population Architecture using Genomics and Epidemiology (PAGE) study
por: Fesinmeyer, Megan D, et al.
Publicado: (2013)

Ablation for long QT syndrome: local or global repolarization effects?
por: Wichterle, Dan, et al.
Publicado: (2023)

The Influence of Obesity-Related Single Nucleotide Polymorphisms on BMI Across the Life Course: The PAGE Study
por: Graff, Mariaelisa, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_plgjqnt2jl4s33cj3ejuq7pbdb