A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier

Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We...

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Autores principales: Bae, Joong Ho, Sohn, Joo Hyun, Lee, Hye Soon, Park, Hye Sun, Hyun, Yil Sik, Kim, Tae Yeob, Eun, Chang Soo, Jeon, Yong Cheol, Han, Dong Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association for the Study of the Liver 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415881/
https://www.ncbi.nlm.nih.gov/pubmed/22893874
http://dx.doi.org/10.3350/cmh.2012.18.2.225
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author Bae, Joong Ho
Sohn, Joo Hyun
Lee, Hye Soon
Park, Hye Sun
Hyun, Yil Sik
Kim, Tae Yeob
Eun, Chang Soo
Jeon, Yong Cheol
Han, Dong Soo
author_facet Bae, Joong Ho
Sohn, Joo Hyun
Lee, Hye Soon
Park, Hye Sun
Hyun, Yil Sik
Kim, Tae Yeob
Eun, Chang Soo
Jeon, Yong Cheol
Han, Dong Soo
author_sort Bae, Joong Ho
collection PubMed
description Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We present a case of a previously inactive HBV carrier with an acute severe flare-up during a long-term, very-low-dose (2.5 mg/day) steroid treatment for rheumatoid arthritis. We suggest that even a minimal dose of single-regimen oral steroid can cause reactivation of indolent, inactive HBV.
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spelling pubmed-34158812012-08-14 A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier Bae, Joong Ho Sohn, Joo Hyun Lee, Hye Soon Park, Hye Sun Hyun, Yil Sik Kim, Tae Yeob Eun, Chang Soo Jeon, Yong Cheol Han, Dong Soo Clin Mol Hepatol Case Report Hepatitis B virus (HBV) may be reactivated after chemotherapy or immunosuppressive therapy, and therefore administration of antiviral agents before such treatment is recommended. Most reported cases of reactivation are associated with high doses of immunosuppressive agents or combination therapy. We present a case of a previously inactive HBV carrier with an acute severe flare-up during a long-term, very-low-dose (2.5 mg/day) steroid treatment for rheumatoid arthritis. We suggest that even a minimal dose of single-regimen oral steroid can cause reactivation of indolent, inactive HBV. The Korean Association for the Study of the Liver 2012-06 2012-06-26 /pmc/articles/PMC3415881/ /pubmed/22893874 http://dx.doi.org/10.3350/cmh.2012.18.2.225 Text en Copyright © 2012 by The Korean Association for the Study of the Liver http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bae, Joong Ho
Sohn, Joo Hyun
Lee, Hye Soon
Park, Hye Sun
Hyun, Yil Sik
Kim, Tae Yeob
Eun, Chang Soo
Jeon, Yong Cheol
Han, Dong Soo
A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
title A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
title_full A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
title_fullStr A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
title_full_unstemmed A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
title_short A fatal case of hepatitis B virus (HBV) reactivation during long-term, very-low-dose steroid treatment in an inactive HBV carrier
title_sort fatal case of hepatitis b virus (hbv) reactivation during long-term, very-low-dose steroid treatment in an inactive hbv carrier
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3415881/
https://www.ncbi.nlm.nih.gov/pubmed/22893874
http://dx.doi.org/10.3350/cmh.2012.18.2.225
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