Efficient inhibition of HIV-1 replication by an artificial polycistronic miRNA construct

BACKGROUND: RNA interference (RNAi) has been used as a promising approach to inhibit human immunodeficiency virus type 1 (HIV-1) replication for both in vitro and in vivo animal models. However, HIV-1 escape mutants after RNAi treatment have been reported. Expressing multiple small interfering RNAs...

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Detalles Bibliográficos
Autores principales: Zhang, Tao, Cheng, Tong, Wei, Lihua, Cai, Yijun, Yeo, Anthony Et, Han, Jiahuai, Yuan, Y Adam, Zhang, Jun, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416660/
https://www.ncbi.nlm.nih.gov/pubmed/22709537
http://dx.doi.org/10.1186/1743-422X-9-118

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