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Crystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking subsite C6
BACKGROUND: Influenza neuraminidase (NA) is an important target for antiviral inhibitors since its active site is highly conserved such that inhibitors can be cross-reactive against multiple types and subtypes of influenza. Here, we discuss the crystal structure of neuraminidase subtype N9 complexed...
Autores principales: | Venkatramani, Lalitha, Johnson, Eric S, Kolavi, Gundurao, Air, Gillian M, Brouillette, Wayne J, Mooers, Blaine HM |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416664/ https://www.ncbi.nlm.nih.gov/pubmed/22559154 http://dx.doi.org/10.1186/1472-6807-12-7 |
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