Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania

Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced sensit...

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Autores principales: Färnert, Anna, Ursing, Johan, Tolfvenstam, Thomas, Rono, Josea, Karlsson, Lillemor, Sparrelid, Elda, Lindegårdh, Niklas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416680/
https://www.ncbi.nlm.nih.gov/pubmed/22632033
http://dx.doi.org/10.1186/1475-2875-11-176
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author Färnert, Anna
Ursing, Johan
Tolfvenstam, Thomas
Rono, Josea
Karlsson, Lillemor
Sparrelid, Elda
Lindegårdh, Niklas
author_facet Färnert, Anna
Ursing, Johan
Tolfvenstam, Thomas
Rono, Josea
Karlsson, Lillemor
Sparrelid, Elda
Lindegårdh, Niklas
author_sort Färnert, Anna
collection PubMed
description Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced sensitivity. Potential sub-optimal effect of artemether-lumefantrine highlights the need to follow non-immune individuals the weeks after treatment.
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spelling pubmed-34166802012-08-11 Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania Färnert, Anna Ursing, Johan Tolfvenstam, Thomas Rono, Josea Karlsson, Lillemor Sparrelid, Elda Lindegårdh, Niklas Malar J Case Report Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced sensitivity. Potential sub-optimal effect of artemether-lumefantrine highlights the need to follow non-immune individuals the weeks after treatment. BioMed Central 2012-05-25 /pmc/articles/PMC3416680/ /pubmed/22632033 http://dx.doi.org/10.1186/1475-2875-11-176 Text en Copyright ©2012 Färnert et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Färnert, Anna
Ursing, Johan
Tolfvenstam, Thomas
Rono, Josea
Karlsson, Lillemor
Sparrelid, Elda
Lindegårdh, Niklas
Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania
title Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania
title_full Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania
title_fullStr Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania
title_full_unstemmed Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania
title_short Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania
title_sort artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with plasmodium falciparum malaria after returning from tanzania
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416680/
https://www.ncbi.nlm.nih.gov/pubmed/22632033
http://dx.doi.org/10.1186/1475-2875-11-176
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