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Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment

The enzyme APOBEC3G (A3G) mutates the human immunodeficiency virus (HIV) genome by converting deoxycytidine (dC) to deoxyuridine (dU) on minus strand viral DNA during reverse transcription. A3G restricts viral propagation by degrading or incapacitating the coding ability of the HIV genome. Thus, thi...

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Detalles Bibliográficos
Autores principales:	Monajemi, Mahdis, Woodworth, Claire F, Benkaroun, Jessica, Grant, Michael, Larijani, Mani
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416701/ https://www.ncbi.nlm.nih.gov/pubmed/22546055 http://dx.doi.org/10.1186/1742-4690-9-35

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