Cargando…

Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study

BACKGROUND: Aim of this pilot study is to examine the effects of myo-inositol administration on ovarian response and oocytes and embryos quality in non PolyCystic Ovary Syndrome (PCOS) patients undergoing multiple follicular stimulation and in vitro insemination by conventional in vitro fertilizatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Lisi, Franco, Carfagna, Piero, Oliva, Mario Montanino, Rago, Rocco, Lisi, Rosella, Poverini, Roberta, Manna, Claudio, Vaquero, Elena, Caserta, Donatella, Raparelli, Valeria, Marci, Roberto, Moscarini, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416732/
https://www.ncbi.nlm.nih.gov/pubmed/22823904
http://dx.doi.org/10.1186/1477-7827-10-52
_version_ 1782240433441603584
author Lisi, Franco
Carfagna, Piero
Oliva, Mario Montanino
Rago, Rocco
Lisi, Rosella
Poverini, Roberta
Manna, Claudio
Vaquero, Elena
Caserta, Donatella
Raparelli, Valeria
Marci, Roberto
Moscarini, Massimo
author_facet Lisi, Franco
Carfagna, Piero
Oliva, Mario Montanino
Rago, Rocco
Lisi, Rosella
Poverini, Roberta
Manna, Claudio
Vaquero, Elena
Caserta, Donatella
Raparelli, Valeria
Marci, Roberto
Moscarini, Massimo
author_sort Lisi, Franco
collection PubMed
description BACKGROUND: Aim of this pilot study is to examine the effects of myo-inositol administration on ovarian response and oocytes and embryos quality in non PolyCystic Ovary Syndrome (PCOS) patients undergoing multiple follicular stimulation and in vitro insemination by conventional in vitro fertilization or by intracytoplasmic sperm injection. METHODS: One hundred non-PCOS women aged <40 years and with basal FSH <10 mUI/ml were down-regulated with triptorelin acetate from the mid-luteal phase for 2 weeks, before starting the stimulation protocol for oocytes recovery. All patients received rFSH, at a starting dose of 150 IU for 6 days. The dose was subsequently adjusted according to individual response. Group B (n = 50) received myo-inositol and folic acid for 3 months before the stimulation period and then during the stimulation itself. Group A (n-50) received only folic acid as additional treatment in the 3 months before and through treatment. RESULTS: Total length of the stimulation was similar between the two groups. Nevertheless, total amount of gonadotropins used to reach follicular maturation was found significantly lower in group B. In addition, the number of oocytes retrieved was significantly reduced in the group pretreated with myo-inositol. Clinical pregnancy and implantation rate were not significantly different in the two groups. CONCLUSIONS: Our findings suggest that the addition of myo-inositol to folic acid in non PCOS-patients undergoing multiple follicular stimulation for in-vitro fertilization may reduce the numbers of mature oocytes and the dosage of rFSH whilst maintaining clinical pregnancy rate. Further, a trend in favor of increased incidence of implantation in the group pretreated with myo-inositol was apparent in this study. Further investigations are warranted to clarify this pharmacological approach, and the benefit it may hold for patients.
format Online
Article
Text
id pubmed-3416732
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-34167322012-08-11 Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study Lisi, Franco Carfagna, Piero Oliva, Mario Montanino Rago, Rocco Lisi, Rosella Poverini, Roberta Manna, Claudio Vaquero, Elena Caserta, Donatella Raparelli, Valeria Marci, Roberto Moscarini, Massimo Reprod Biol Endocrinol Research BACKGROUND: Aim of this pilot study is to examine the effects of myo-inositol administration on ovarian response and oocytes and embryos quality in non PolyCystic Ovary Syndrome (PCOS) patients undergoing multiple follicular stimulation and in vitro insemination by conventional in vitro fertilization or by intracytoplasmic sperm injection. METHODS: One hundred non-PCOS women aged <40 years and with basal FSH <10 mUI/ml were down-regulated with triptorelin acetate from the mid-luteal phase for 2 weeks, before starting the stimulation protocol for oocytes recovery. All patients received rFSH, at a starting dose of 150 IU for 6 days. The dose was subsequently adjusted according to individual response. Group B (n = 50) received myo-inositol and folic acid for 3 months before the stimulation period and then during the stimulation itself. Group A (n-50) received only folic acid as additional treatment in the 3 months before and through treatment. RESULTS: Total length of the stimulation was similar between the two groups. Nevertheless, total amount of gonadotropins used to reach follicular maturation was found significantly lower in group B. In addition, the number of oocytes retrieved was significantly reduced in the group pretreated with myo-inositol. Clinical pregnancy and implantation rate were not significantly different in the two groups. CONCLUSIONS: Our findings suggest that the addition of myo-inositol to folic acid in non PCOS-patients undergoing multiple follicular stimulation for in-vitro fertilization may reduce the numbers of mature oocytes and the dosage of rFSH whilst maintaining clinical pregnancy rate. Further, a trend in favor of increased incidence of implantation in the group pretreated with myo-inositol was apparent in this study. Further investigations are warranted to clarify this pharmacological approach, and the benefit it may hold for patients. BioMed Central 2012-07-23 /pmc/articles/PMC3416732/ /pubmed/22823904 http://dx.doi.org/10.1186/1477-7827-10-52 Text en Copyright ©2012 Lisi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Lisi, Franco
Carfagna, Piero
Oliva, Mario Montanino
Rago, Rocco
Lisi, Rosella
Poverini, Roberta
Manna, Claudio
Vaquero, Elena
Caserta, Donatella
Raparelli, Valeria
Marci, Roberto
Moscarini, Massimo
Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study
title Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study
title_full Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study
title_fullStr Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study
title_full_unstemmed Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study
title_short Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study
title_sort pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for ivf: a pilot study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416732/
https://www.ncbi.nlm.nih.gov/pubmed/22823904
http://dx.doi.org/10.1186/1477-7827-10-52
work_keys_str_mv AT lisifranco pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy
AT carfagnapiero pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy
AT olivamariomontanino pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy
AT ragorocco pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy
AT lisirosella pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy
AT poveriniroberta pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy
AT mannaclaudio pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy
AT vaqueroelena pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy
AT casertadonatella pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy
AT raparellivaleria pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy
AT marciroberto pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy
AT moscarinimassimo pretreatmentwithmyoinositolinnonpolycysticovarysyndromepatientsundergoingmultiplefollicularstimulationforivfapilotstudy