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α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation

BACKGROUND: Although evidence suggests that the prevalence of Parkinson’s disease (PD) is lower in smokers than in non-smokers, the mechanisms of nicotine-induced neuroprotection remain unclear. Stimulation of the α7 nicotinic acetylcholine receptor (α7-nAChR) seems to be a crucial mechanism underly...

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Detalles Bibliográficos
Autores principales:	Liu, Yuan, Hu, Jun, Wu, Jie, Zhu, Chenlei, Hui, Yujian, Han, Yaping, Huang, Zuhu, Ellsworth, Kevin, Fan, Weimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416733/ https://www.ncbi.nlm.nih.gov/pubmed/22624500 http://dx.doi.org/10.1186/1742-2094-9-98

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