Alteration of POLDIP3 Splicing Associated with Loss of Function of TDP-43 in Tissues Affected with ALS

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease caused by selective loss of motor neurons. In the ALS motor neurons, TAR DNA-binding protein of 43 kDa (TDP-43) is dislocated from the nucleus to cytoplasm and forms inclusions, suggesting that loss of a nuclear function...

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Detalles Bibliográficos
Autores principales: Shiga, Atsushi, Ishihara, Tomohiko, Miyashita, Akinori, Kuwabara, Misaki, Kato, Taisuke, Watanabe, Norihiro, Yamahira, Akie, Kondo, Chigusa, Yokoseki, Akio, Takahashi, Masuhiro, Kuwano, Ryozo, Kakita, Akiyoshi, Nishizawa, Masatoyo, Takahashi, Hitoshi, Onodera, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416794/
https://www.ncbi.nlm.nih.gov/pubmed/22900096
http://dx.doi.org/10.1371/journal.pone.0043120

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