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Negative Selection Assay Based on Stimulation of T Cell Receptor Transgenic Thymocytes with Peptide-MHC Tetramers

Thymocyte negative selection is a requirement for the development of self tolerance. Although it is possible to assay the induction of cell death in thymocytes in vitro using antibody cross-linking, this stimulus is much stronger than the normal range of T cell receptor ligands that could be encount...

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Detalles Bibliográficos
Autores principales:	Rybakin, Vasily, Gascoigne, Nicholas R. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416795/ https://www.ncbi.nlm.nih.gov/pubmed/22900100 http://dx.doi.org/10.1371/journal.pone.0043191

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