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Novel In Situ Pretreatment Method for Significantly Enhancing the Signal In MALDI-TOF MS of Formalin-Fixed Paraffin-Embedded Tissue Sections

The application of matrix-assisted laser desorption/ionization (MALDI)-based mass spectrometry (MS) to the proteomic analysis of formalin-fixed paraffin-embedded (FFPE) tissue presents significant technical challenges. In situ enzymatic digestion is frequently used to unlock formalin-fixed tissues f...

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Detalles Bibliográficos
Autores principales:	Kakimoto, Yu, Tsuruyama, Tatsuaki, Yamamoto, Takushi, Furuta, Masaru, Kotani, Hirokazu, Ozeki, Munetaka, Yoshizawa, Akihiko, Haga, Hironori, Tamaki, Keiji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3416821/ https://www.ncbi.nlm.nih.gov/pubmed/22899997 http://dx.doi.org/10.1371/journal.pone.0041607

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