The intestinal epithelium tuft cells: specification and function

The intestinal epithelium, composed of at least seven differentiated cell types, represents an extraordinary model to understand the details of multi-lineage differentiation, a question that is highly relevant in developmental biology as well as for clinical applications. This review focuses on inte...

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Detalles Bibliográficos
Autores principales: Gerbe, François, Legraverend, Catherine, Jay, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417095/
https://www.ncbi.nlm.nih.gov/pubmed/22527717
http://dx.doi.org/10.1007/s00018-012-0984-7
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author Gerbe, François
Legraverend, Catherine
Jay, Philippe
author_facet Gerbe, François
Legraverend, Catherine
Jay, Philippe
author_sort Gerbe, François
collection PubMed
description The intestinal epithelium, composed of at least seven differentiated cell types, represents an extraordinary model to understand the details of multi-lineage differentiation, a question that is highly relevant in developmental biology as well as for clinical applications. This review focuses on intestinal epithelial tuft cells that have been acknowledged as a separate entity for more than 60 years but whose function remains a mystery. We discuss what is currently known about the molecular basis of tuft cell fate and differentiation and why elucidating tuft cell function has been so difficult. Finally, we summarize the current hypotheses on their potential involvement in diseases of the gastro-intestinal tract.
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spelling pubmed-34170952012-08-23 The intestinal epithelium tuft cells: specification and function Gerbe, François Legraverend, Catherine Jay, Philippe Cell Mol Life Sci Review The intestinal epithelium, composed of at least seven differentiated cell types, represents an extraordinary model to understand the details of multi-lineage differentiation, a question that is highly relevant in developmental biology as well as for clinical applications. This review focuses on intestinal epithelial tuft cells that have been acknowledged as a separate entity for more than 60 years but whose function remains a mystery. We discuss what is currently known about the molecular basis of tuft cell fate and differentiation and why elucidating tuft cell function has been so difficult. Finally, we summarize the current hypotheses on their potential involvement in diseases of the gastro-intestinal tract. SP Birkhäuser Verlag Basel 2012-04-19 2012 /pmc/articles/PMC3417095/ /pubmed/22527717 http://dx.doi.org/10.1007/s00018-012-0984-7 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Gerbe, François
Legraverend, Catherine
Jay, Philippe
The intestinal epithelium tuft cells: specification and function
title The intestinal epithelium tuft cells: specification and function
title_full The intestinal epithelium tuft cells: specification and function
title_fullStr The intestinal epithelium tuft cells: specification and function
title_full_unstemmed The intestinal epithelium tuft cells: specification and function
title_short The intestinal epithelium tuft cells: specification and function
title_sort intestinal epithelium tuft cells: specification and function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417095/
https://www.ncbi.nlm.nih.gov/pubmed/22527717
http://dx.doi.org/10.1007/s00018-012-0984-7
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