In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts from Argentinean Mikania Species

The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia, and M. cordifolia were tested on Trypanosoma cruzi epimastigotes, Leishmania braziliensis pro...

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Autores principales: Laurella, Laura C., Frank, Fernanda M., Sarquiz, Andrea, Alonso, María R., Giberti, Gustavo, Cavallaro, Lucia, Catalán, Cesar A., Cazorla, Silvia I., Malchiodi, Emilio, Martino, Virginia S., Sülsen, Valeria P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417183/
https://www.ncbi.nlm.nih.gov/pubmed/22919289
http://dx.doi.org/10.1100/2012/121253
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author Laurella, Laura C.
Frank, Fernanda M.
Sarquiz, Andrea
Alonso, María R.
Giberti, Gustavo
Cavallaro, Lucia
Catalán, Cesar A.
Cazorla, Silvia I.
Malchiodi, Emilio
Martino, Virginia S.
Sülsen, Valeria P.
author_facet Laurella, Laura C.
Frank, Fernanda M.
Sarquiz, Andrea
Alonso, María R.
Giberti, Gustavo
Cavallaro, Lucia
Catalán, Cesar A.
Cazorla, Silvia I.
Malchiodi, Emilio
Martino, Virginia S.
Sülsen, Valeria P.
author_sort Laurella, Laura C.
collection PubMed
description The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia, and M. cordifolia were tested on Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes, and dengue virus type 2. The organic extract of M. micrantha was the most active against T. cruzi and L. braziliensis exhibiting a growth inhibition of 77.6 ± 4.5% and 84.9 ± 6.1%, respectively, at a concentration of 10 μg/ml. The bioguided fractionation of M. micrantha organic extract led to the identification of two active fractions. The chromatographic profile and infrared analysis of these fractions revealed the presence of sesquiterpene lactones. None of the tested extracts were active against dengue virus type 2.
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spelling pubmed-34171832012-08-23 In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts from Argentinean Mikania Species Laurella, Laura C. Frank, Fernanda M. Sarquiz, Andrea Alonso, María R. Giberti, Gustavo Cavallaro, Lucia Catalán, Cesar A. Cazorla, Silvia I. Malchiodi, Emilio Martino, Virginia S. Sülsen, Valeria P. ScientificWorldJournal Research Article The aim of this study was to investigate the antiprotozoal and antiviral activities of four Argentinean Mikania species. The organic and aqueous extracts of Mikania micrantha, M. parodii, M. periplocifolia, and M. cordifolia were tested on Trypanosoma cruzi epimastigotes, Leishmania braziliensis promastigotes, and dengue virus type 2. The organic extract of M. micrantha was the most active against T. cruzi and L. braziliensis exhibiting a growth inhibition of 77.6 ± 4.5% and 84.9 ± 6.1%, respectively, at a concentration of 10 μg/ml. The bioguided fractionation of M. micrantha organic extract led to the identification of two active fractions. The chromatographic profile and infrared analysis of these fractions revealed the presence of sesquiterpene lactones. None of the tested extracts were active against dengue virus type 2. The Scientific World Journal 2012-07-31 /pmc/articles/PMC3417183/ /pubmed/22919289 http://dx.doi.org/10.1100/2012/121253 Text en Copyright © 2012 Laura C. Laurella et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Laurella, Laura C.
Frank, Fernanda M.
Sarquiz, Andrea
Alonso, María R.
Giberti, Gustavo
Cavallaro, Lucia
Catalán, Cesar A.
Cazorla, Silvia I.
Malchiodi, Emilio
Martino, Virginia S.
Sülsen, Valeria P.
In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts from Argentinean Mikania Species
title In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts from Argentinean Mikania Species
title_full In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts from Argentinean Mikania Species
title_fullStr In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts from Argentinean Mikania Species
title_full_unstemmed In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts from Argentinean Mikania Species
title_short In Vitro Evaluation of Antiprotozoal and Antiviral Activities of Extracts from Argentinean Mikania Species
title_sort in vitro evaluation of antiprotozoal and antiviral activities of extracts from argentinean mikania species
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417183/
https://www.ncbi.nlm.nih.gov/pubmed/22919289
http://dx.doi.org/10.1100/2012/121253
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