Cargando…

Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet

Colorectal cancer (CRC) is a leading cause of cancer deaths in the United States. Various risk factors have been associated with CRC including increasing age and diet. Epidemiological and experimental studies have implicated a diet high in fat as an important risk factor for colon cancer. High fat d...

Descripción completa

Detalles Bibliográficos
Autores principales: Pettan-Brewer, Christina, Morton, John, Mangalindan, Ruby, Ladiges, Warren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417547/
https://www.ncbi.nlm.nih.gov/pubmed/22953026
http://dx.doi.org/10.3402/pba.v1i0.7013
_version_ 1782240511113822208
author Pettan-Brewer, Christina
Morton, John
Mangalindan, Ruby
Ladiges, Warren
author_facet Pettan-Brewer, Christina
Morton, John
Mangalindan, Ruby
Ladiges, Warren
author_sort Pettan-Brewer, Christina
collection PubMed
description Colorectal cancer (CRC) is a leading cause of cancer deaths in the United States. Various risk factors have been associated with CRC including increasing age and diet. Epidemiological and experimental studies have implicated a diet high in fat as an important risk factor for colon cancer. High fat diets can promote obesity resulting in insulin resistance and inflammation and the development of oxidative stress, increased cell proliferation, and suppression of apoptosis. Because of the high consumption of dietary fats, especially saturated fats, by Western countries, it is of interest to see if non-nutrient food factors might be effective in preventing or delaying CRC in the presence of high saturated fat intake. Curcumin (Curcuma longa), the main yellow pigment in turmeric, was selected to test because of its reported anti-tumor activity. APC Min mice, which develop intestinal polyps and have many molecular features of CRC, were fed a diet containing 35% pork fat, 33% sucrose, and a protein and vitamin mineral mixture (HFD) with or without 0.5% curcumin. These cohorts were compared to APC Min mice receiving standard rodent chow (RC) with 8% fat. APC Min mice fed the HFD for 3 months had a 23% increase in total number of polyps compared to APC Min mice on RC. Curcumin was able to significantly reverse the accelerated polyp development associated with the HFD suggesting it may be effective clinically in helping prevent colon cancer even when ingesting high amounts of fatty foods. The anti-tumor effect of curcumin was shown to be associated with enhanced apoptosis and increased efficiency of DNA repair. Since curcumin prevented the gain in body weight seen in APC Min mice ingesting the HFD, modulation of energy metabolism may also be a factor.
format Online
Article
Text
id pubmed-3417547
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Co-Action Publishing
record_format MEDLINE/PubMed
spelling pubmed-34175472012-09-05 Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet Pettan-Brewer, Christina Morton, John Mangalindan, Ruby Ladiges, Warren Pathobiol Aging Age Relat Dis Brief Report Colorectal cancer (CRC) is a leading cause of cancer deaths in the United States. Various risk factors have been associated with CRC including increasing age and diet. Epidemiological and experimental studies have implicated a diet high in fat as an important risk factor for colon cancer. High fat diets can promote obesity resulting in insulin resistance and inflammation and the development of oxidative stress, increased cell proliferation, and suppression of apoptosis. Because of the high consumption of dietary fats, especially saturated fats, by Western countries, it is of interest to see if non-nutrient food factors might be effective in preventing or delaying CRC in the presence of high saturated fat intake. Curcumin (Curcuma longa), the main yellow pigment in turmeric, was selected to test because of its reported anti-tumor activity. APC Min mice, which develop intestinal polyps and have many molecular features of CRC, were fed a diet containing 35% pork fat, 33% sucrose, and a protein and vitamin mineral mixture (HFD) with or without 0.5% curcumin. These cohorts were compared to APC Min mice receiving standard rodent chow (RC) with 8% fat. APC Min mice fed the HFD for 3 months had a 23% increase in total number of polyps compared to APC Min mice on RC. Curcumin was able to significantly reverse the accelerated polyp development associated with the HFD suggesting it may be effective clinically in helping prevent colon cancer even when ingesting high amounts of fatty foods. The anti-tumor effect of curcumin was shown to be associated with enhanced apoptosis and increased efficiency of DNA repair. Since curcumin prevented the gain in body weight seen in APC Min mice ingesting the HFD, modulation of energy metabolism may also be a factor. Co-Action Publishing 2011-06-01 /pmc/articles/PMC3417547/ /pubmed/22953026 http://dx.doi.org/10.3402/pba.v1i0.7013 Text en © 2011 Christina Pettan-Brewer et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Pettan-Brewer, Christina
Morton, John
Mangalindan, Ruby
Ladiges, Warren
Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet
title Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet
title_full Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet
title_fullStr Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet
title_full_unstemmed Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet
title_short Curcumin suppresses intestinal polyps in APC Min mice fed a high fat diet
title_sort curcumin suppresses intestinal polyps in apc min mice fed a high fat diet
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417547/
https://www.ncbi.nlm.nih.gov/pubmed/22953026
http://dx.doi.org/10.3402/pba.v1i0.7013
work_keys_str_mv AT pettanbrewerchristina curcuminsuppressesintestinalpolypsinapcminmicefedahighfatdiet
AT mortonjohn curcuminsuppressesintestinalpolypsinapcminmicefedahighfatdiet
AT mangalindanruby curcuminsuppressesintestinalpolypsinapcminmicefedahighfatdiet
AT ladigeswarren curcuminsuppressesintestinalpolypsinapcminmicefedahighfatdiet