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Resistance of Francisella Novicida to Fosmidomycin Associated with Mutations in the Glycerol-3-Phosphate Transporter

The methylerythritol phosphate (MEP) pathway is essential in most prokaryotes and some lower eukaryotes but absent from human cells, and is a validated target for antimicrobial drug development. The formation of MEP is catalyzed by 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR). MEP pathway g...

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Detalles Bibliográficos
Autores principales:	Mackie, Ryan S., McKenney, Elizabeth S., van Hoek, Monique L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417576/ https://www.ncbi.nlm.nih.gov/pubmed/22905031 http://dx.doi.org/10.3389/fmicb.2012.00226

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