Cargando…

Mycoplasma genitalium presence, resistance and epidemiology in Greenland

OBJECTIVES: Greenland reports the highest rates of chlamydial infection and gonorrhea in the Arctic. Our objective was to determine the presence, and describe the basic epidemiology, of Mycoplasma genitalium for Greenland. STUDY DESIGN: Cross-sectional study. METHODS: 314 residents from Nuuk and Sis...

Descripción completa

Detalles Bibliográficos
Autores principales: Gesink, Dionne C., Mulvad, Gert, Montgomery-Andersen, Ruth, Poppel, Upaluk, Montgomery-Andersen, Stephan, Binzer, Aka, Vernich, Lee, Frosst, Gillian, Stenz, Flemming, Rink, Elizabeth, Rosing Olsen, Ove, Koch, Anders, Skov Jensen, Jørgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417636/
https://www.ncbi.nlm.nih.gov/pubmed/22564463
http://dx.doi.org/10.3402/ijch.v71i0.18203
_version_ 1782240523709317120
author Gesink, Dionne C.
Mulvad, Gert
Montgomery-Andersen, Ruth
Poppel, Upaluk
Montgomery-Andersen, Stephan
Binzer, Aka
Vernich, Lee
Frosst, Gillian
Stenz, Flemming
Rink, Elizabeth
Rosing Olsen, Ove
Koch, Anders
Skov Jensen, Jørgen
author_facet Gesink, Dionne C.
Mulvad, Gert
Montgomery-Andersen, Ruth
Poppel, Upaluk
Montgomery-Andersen, Stephan
Binzer, Aka
Vernich, Lee
Frosst, Gillian
Stenz, Flemming
Rink, Elizabeth
Rosing Olsen, Ove
Koch, Anders
Skov Jensen, Jørgen
author_sort Gesink, Dionne C.
collection PubMed
description OBJECTIVES: Greenland reports the highest rates of chlamydial infection and gonorrhea in the Arctic. Our objective was to determine the presence, and describe the basic epidemiology, of Mycoplasma genitalium for Greenland. STUDY DESIGN: Cross-sectional study. METHODS: 314 residents from Nuuk and Sisimiut, between the ages of 15 and 65 years, participated in “Inuulluataarneq” (the Greenland Sexual Health Project) between July 2008 and November 2009. Participants provided self-collected samples for sexually transmitted infection (STI) testing and completed a sexual health survey. Descriptive statistics and logistic regression were used to summarize the basic characteristics of STI cases overall and M. genitalium and Chlamydia trachomatis specifically. Clinically relevant characteristics in each full model were gender (male or female), age (in years), age at sexual debut (in years), number of sexual partners in the past 3 months (continuous) and history of forced sex and community. RESULTS: The overall prevalence of STIs was 19.0%, specifically: 9.8% for M. genitalium and 9.4% for C. trachomatis; 100% of M. genitalium-positive cases carried macrolide resistance determinants. Being female [OR =3.2; 95% confidence interval (CI): 1.1–9.8] and younger age (OR=0.9; 95% CI: 0.9–1.0) were associated with M. genitalium positivity. Age was also associated with C. trachomatis (OR=0.9; 95% CI: 0.8–0.9) and STI positivity overall (OR=0.9; 95% CI: 0.9–0.9). CONCLUSIONS: We observed a high prevalence of M. genitalium and macrolide resistance in this study. A better understanding of M. genitalium sequelae is needed to inform policy around testing, treatment, control and antibiotic use.
format Online
Article
Text
id pubmed-3417636
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Co-Action Publishing
record_format MEDLINE/PubMed
spelling pubmed-34176362012-09-06 Mycoplasma genitalium presence, resistance and epidemiology in Greenland Gesink, Dionne C. Mulvad, Gert Montgomery-Andersen, Ruth Poppel, Upaluk Montgomery-Andersen, Stephan Binzer, Aka Vernich, Lee Frosst, Gillian Stenz, Flemming Rink, Elizabeth Rosing Olsen, Ove Koch, Anders Skov Jensen, Jørgen Int J Circumpolar Health Original Research Article OBJECTIVES: Greenland reports the highest rates of chlamydial infection and gonorrhea in the Arctic. Our objective was to determine the presence, and describe the basic epidemiology, of Mycoplasma genitalium for Greenland. STUDY DESIGN: Cross-sectional study. METHODS: 314 residents from Nuuk and Sisimiut, between the ages of 15 and 65 years, participated in “Inuulluataarneq” (the Greenland Sexual Health Project) between July 2008 and November 2009. Participants provided self-collected samples for sexually transmitted infection (STI) testing and completed a sexual health survey. Descriptive statistics and logistic regression were used to summarize the basic characteristics of STI cases overall and M. genitalium and Chlamydia trachomatis specifically. Clinically relevant characteristics in each full model were gender (male or female), age (in years), age at sexual debut (in years), number of sexual partners in the past 3 months (continuous) and history of forced sex and community. RESULTS: The overall prevalence of STIs was 19.0%, specifically: 9.8% for M. genitalium and 9.4% for C. trachomatis; 100% of M. genitalium-positive cases carried macrolide resistance determinants. Being female [OR =3.2; 95% confidence interval (CI): 1.1–9.8] and younger age (OR=0.9; 95% CI: 0.9–1.0) were associated with M. genitalium positivity. Age was also associated with C. trachomatis (OR=0.9; 95% CI: 0.8–0.9) and STI positivity overall (OR=0.9; 95% CI: 0.9–0.9). CONCLUSIONS: We observed a high prevalence of M. genitalium and macrolide resistance in this study. A better understanding of M. genitalium sequelae is needed to inform policy around testing, treatment, control and antibiotic use. Co-Action Publishing 2012-04-16 /pmc/articles/PMC3417636/ /pubmed/22564463 http://dx.doi.org/10.3402/ijch.v71i0.18203 Text en © 2012 Dionne C. Gesink et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Gesink, Dionne C.
Mulvad, Gert
Montgomery-Andersen, Ruth
Poppel, Upaluk
Montgomery-Andersen, Stephan
Binzer, Aka
Vernich, Lee
Frosst, Gillian
Stenz, Flemming
Rink, Elizabeth
Rosing Olsen, Ove
Koch, Anders
Skov Jensen, Jørgen
Mycoplasma genitalium presence, resistance and epidemiology in Greenland
title Mycoplasma genitalium presence, resistance and epidemiology in Greenland
title_full Mycoplasma genitalium presence, resistance and epidemiology in Greenland
title_fullStr Mycoplasma genitalium presence, resistance and epidemiology in Greenland
title_full_unstemmed Mycoplasma genitalium presence, resistance and epidemiology in Greenland
title_short Mycoplasma genitalium presence, resistance and epidemiology in Greenland
title_sort mycoplasma genitalium presence, resistance and epidemiology in greenland
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417636/
https://www.ncbi.nlm.nih.gov/pubmed/22564463
http://dx.doi.org/10.3402/ijch.v71i0.18203
work_keys_str_mv AT gesinkdionnec mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT mulvadgert mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT montgomeryandersenruth mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT poppelupaluk mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT montgomeryandersenstephan mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT binzeraka mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT vernichlee mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT frosstgillian mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT stenzflemming mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT rinkelizabeth mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT rosingolsenove mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT kochanders mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland
AT skovjensenjørgen mycoplasmagenitaliumpresenceresistanceandepidemiologyingreenland