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Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis

The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF(®), represents the water soluble fraction contai...

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Autores principales: Rafehi, Haloom, Ververis, Katherine, Balcerczyk, Aneta, Ziemann, Mark, Ooi, Jenny, Hu, Sean, Kwa, Faith A. A., Loveridge, Shanon J., Georgiadis, George T., El-Osta, Assam, Karagiannis, Tom C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Co-Action Publishing 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417697/
https://www.ncbi.nlm.nih.gov/pubmed/22953038
http://dx.doi.org/10.3402/pba.v2i0.11905
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author Rafehi, Haloom
Ververis, Katherine
Balcerczyk, Aneta
Ziemann, Mark
Ooi, Jenny
Hu, Sean
Kwa, Faith A. A.
Loveridge, Shanon J.
Georgiadis, George T.
El-Osta, Assam
Karagiannis, Tom C.
author_facet Rafehi, Haloom
Ververis, Katherine
Balcerczyk, Aneta
Ziemann, Mark
Ooi, Jenny
Hu, Sean
Kwa, Faith A. A.
Loveridge, Shanon J.
Georgiadis, George T.
El-Osta, Assam
Karagiannis, Tom C.
author_sort Rafehi, Haloom
collection PubMed
description The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF(®), represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.
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spelling pubmed-34176972012-09-05 Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis Rafehi, Haloom Ververis, Katherine Balcerczyk, Aneta Ziemann, Mark Ooi, Jenny Hu, Sean Kwa, Faith A. A. Loveridge, Shanon J. Georgiadis, George T. El-Osta, Assam Karagiannis, Tom C. Pathobiol Aging Age Relat Dis Research Paper The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes, a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF(®), represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was to utilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by Cinnulin PF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation. Co-Action Publishing 2012-02-22 /pmc/articles/PMC3417697/ /pubmed/22953038 http://dx.doi.org/10.3402/pba.v2i0.11905 Text en © 2012 Haloom Rafehi et al. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Rafehi, Haloom
Ververis, Katherine
Balcerczyk, Aneta
Ziemann, Mark
Ooi, Jenny
Hu, Sean
Kwa, Faith A. A.
Loveridge, Shanon J.
Georgiadis, George T.
El-Osta, Assam
Karagiannis, Tom C.
Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis
title Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis
title_full Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis
title_fullStr Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis
title_full_unstemmed Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis
title_short Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis
title_sort investigation of the biological properties of cinnulin pf in the context of diabetes: mechanistic insights by genome-wide mrna-seq analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417697/
https://www.ncbi.nlm.nih.gov/pubmed/22953038
http://dx.doi.org/10.3402/pba.v2i0.11905
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