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Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases

Midkine is a heparin-binding cytokine or a growth factor with a molecular weight of 13 kDa. Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate. The midkine receptor is a molecular complex containing proteoglycans. Midkine promotes migration, survival and other activi...

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Detalles Bibliográficos
Autor principal: Muramatsu, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417803/
https://www.ncbi.nlm.nih.gov/pubmed/20431264
http://dx.doi.org/10.2183/pjab.86.410
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author Muramatsu, Takashi
author_facet Muramatsu, Takashi
author_sort Muramatsu, Takashi
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description Midkine is a heparin-binding cytokine or a growth factor with a molecular weight of 13 kDa. Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate. The midkine receptor is a molecular complex containing proteoglycans. Midkine promotes migration, survival and other activities of target cells. Midkine has about 50% sequence identity with pleiotrophin. Mice deficient in both factors exhibit severe abnormalities including female infertility. In adults, midkine is expressed in damaged tissues and involved in the reparative process. It is also involved in inflammatory reactions by promoting the migration of leukocytes, induction of chemokines and suppression of regulatory T cells. Midkine is expressed in a variety of malignant tumors and promotes their growth and invasion. Midkine appears to be helpful for the treatment of injuries in the heart, brain, spinal cord and retina. Midkine inhibitors are expected to be effective in the treatment of malignancies, rheumatoid arthritis, multiple sclerosis, renal diseases, restenosis, hypertension and adhesion after surgery.
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spelling pubmed-34178032012-11-27 Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases Muramatsu, Takashi Proc Jpn Acad Ser B Phys Biol Sci Review Midkine is a heparin-binding cytokine or a growth factor with a molecular weight of 13 kDa. Midkine binds to oversulfated structures in heparan sulfate and chondroitin sulfate. The midkine receptor is a molecular complex containing proteoglycans. Midkine promotes migration, survival and other activities of target cells. Midkine has about 50% sequence identity with pleiotrophin. Mice deficient in both factors exhibit severe abnormalities including female infertility. In adults, midkine is expressed in damaged tissues and involved in the reparative process. It is also involved in inflammatory reactions by promoting the migration of leukocytes, induction of chemokines and suppression of regulatory T cells. Midkine is expressed in a variety of malignant tumors and promotes their growth and invasion. Midkine appears to be helpful for the treatment of injuries in the heart, brain, spinal cord and retina. Midkine inhibitors are expected to be effective in the treatment of malignancies, rheumatoid arthritis, multiple sclerosis, renal diseases, restenosis, hypertension and adhesion after surgery. The Japan Academy 2010-04 /pmc/articles/PMC3417803/ /pubmed/20431264 http://dx.doi.org/10.2183/pjab.86.410 Text en © 2010 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Muramatsu, Takashi
Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases
title Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases
title_full Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases
title_fullStr Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases
title_full_unstemmed Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases
title_short Midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases
title_sort midkine, a heparin-binding cytokine with multiple roles in development, repair and diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417803/
https://www.ncbi.nlm.nih.gov/pubmed/20431264
http://dx.doi.org/10.2183/pjab.86.410
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