Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity

From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological st...

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Detalles Bibliográficos
Autores principales: Yamada, Kiyoyuki, Ojika, Makoto, Kigoshi, Hideo, Suenaga, Kiyotake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japan Academy 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417844/
https://www.ncbi.nlm.nih.gov/pubmed/20228619
http://dx.doi.org/10.2183/pjab.86.176
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author Yamada, Kiyoyuki
Ojika, Makoto
Kigoshi, Hideo
Suenaga, Kiyotake
author_facet Yamada, Kiyoyuki
Ojika, Makoto
Kigoshi, Hideo
Suenaga, Kiyotake
author_sort Yamada, Kiyoyuki
collection PubMed
description From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.
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spelling pubmed-34178442012-11-29 Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity Yamada, Kiyoyuki Ojika, Makoto Kigoshi, Hideo Suenaga, Kiyotake Proc Jpn Acad Ser B Phys Biol Sci Review From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity. The Japan Academy 2010-03 /pmc/articles/PMC3417844/ /pubmed/20228619 http://dx.doi.org/10.2183/pjab.86.176 Text en © 2010 The Japan Academy This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Yamada, Kiyoyuki
Ojika, Makoto
Kigoshi, Hideo
Suenaga, Kiyotake
Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity
title Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity
title_full Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity
title_fullStr Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity
title_full_unstemmed Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity
title_short Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity
title_sort cytotoxic substances from two species of japanese sea hares: chemistry and bioactivity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417844/
https://www.ncbi.nlm.nih.gov/pubmed/20228619
http://dx.doi.org/10.2183/pjab.86.176
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AT kigoshihideo cytotoxicsubstancesfromtwospeciesofjapaneseseahareschemistryandbioactivity
AT suenagakiyotake cytotoxicsubstancesfromtwospeciesofjapaneseseahareschemistryandbioactivity

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