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Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel
Hyaluronic acid (HA), in linear or cross-linked form, is a common component of cosmetics, personal care products, combination medical products, and medical devices. In all cases, the ability of the HA solution or gel to wet surfaces and/or disrupt and lubricate interfaces is a limiting feature of it...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417868/ https://www.ncbi.nlm.nih.gov/pubmed/22915924 http://dx.doi.org/10.2147/MDER.S13962 |
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author | Vorvolakos, Katherine Isayeva, Irada S Luu, Hoan-My Do Patwardhan, Dinesh V Pollack, Steven K |
author_facet | Vorvolakos, Katherine Isayeva, Irada S Luu, Hoan-My Do Patwardhan, Dinesh V Pollack, Steven K |
author_sort | Vorvolakos, Katherine |
collection | PubMed |
description | Hyaluronic acid (HA), in linear or cross-linked form, is a common component of cosmetics, personal care products, combination medical products, and medical devices. In all cases, the ability of the HA solution or gel to wet surfaces and/or disrupt and lubricate interfaces is a limiting feature of its mechanism of action. We synthesized ferric ion–cross-linked networks of HA based on an adhesion barrier, varied the degree of cross-linking, and performed wetting goniometry, viscometry, and dynamic mechanical analysis. As cross-linking increases, so do contact angle, viscosity, storage modulus, and loss modulus; thus, wetting and lubrication are compromised. These findings have implications in medical device materials, such as adhesion barriers and mucosal drug delivery vehicles. |
format | Online Article Text |
id | pubmed-3417868 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-34178682012-08-22 Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel Vorvolakos, Katherine Isayeva, Irada S Luu, Hoan-My Do Patwardhan, Dinesh V Pollack, Steven K Med Devices (Auckl) Original Research Hyaluronic acid (HA), in linear or cross-linked form, is a common component of cosmetics, personal care products, combination medical products, and medical devices. In all cases, the ability of the HA solution or gel to wet surfaces and/or disrupt and lubricate interfaces is a limiting feature of its mechanism of action. We synthesized ferric ion–cross-linked networks of HA based on an adhesion barrier, varied the degree of cross-linking, and performed wetting goniometry, viscometry, and dynamic mechanical analysis. As cross-linking increases, so do contact angle, viscosity, storage modulus, and loss modulus; thus, wetting and lubrication are compromised. These findings have implications in medical device materials, such as adhesion barriers and mucosal drug delivery vehicles. Dove Medical Press 2010-12-16 /pmc/articles/PMC3417868/ /pubmed/22915924 http://dx.doi.org/10.2147/MDER.S13962 Text en © 2011 Vorvolakos et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Original Research Vorvolakos, Katherine Isayeva, Irada S Luu, Hoan-My Do Patwardhan, Dinesh V Pollack, Steven K Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel |
title | Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel |
title_full | Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel |
title_fullStr | Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel |
title_full_unstemmed | Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel |
title_short | Ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel |
title_sort | ionically cross-linked hyaluronic acid: wetting, lubrication, and viscoelasticity of a modified adhesion barrier gel |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417868/ https://www.ncbi.nlm.nih.gov/pubmed/22915924 http://dx.doi.org/10.2147/MDER.S13962 |
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