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Optimizing use of 5-ASA in the treatment of ulcerative colitis: Focus on patient compliance and adherence

Ulcerative colitis is a chronic condition that requires long-term treatment. The first-line therapy remains 5-ASA, which is available in a variety of different formulations and dosing schedules. Multiple studies have demonstrated that adherence rates to prescribed 5-ASA products is below what would...

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Detalles Bibliográficos
Autores principales: Bernick, Steven J, Kane, Sunanda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417898/
https://www.ncbi.nlm.nih.gov/pubmed/22915953
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author Bernick, Steven J
Kane, Sunanda
author_facet Bernick, Steven J
Kane, Sunanda
author_sort Bernick, Steven J
collection PubMed
description Ulcerative colitis is a chronic condition that requires long-term treatment. The first-line therapy remains 5-ASA, which is available in a variety of different formulations and dosing schedules. Multiple studies have demonstrated that adherence rates to prescribed 5-ASA products is below what would have been expected with significant consequences for important outcomes. Worse disease outcomes, higher medical costs, and even potentially higher rates of colorectal cancer have been associated with nonadherence. Nonadherence is multifactorial, fluid in nature over time, and dependent on disease activity level. Interventions to improve adherence rates have to be individualized. With the advent of simpler dosing regimens it was assumed that adherence rates would improve, but this has not necessarily been the case. Despite our current knowledge about nonadherence, it remains difficult to manage in the long term.
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spelling pubmed-34178982012-08-22 Optimizing use of 5-ASA in the treatment of ulcerative colitis: Focus on patient compliance and adherence Bernick, Steven J Kane, Sunanda Patient Relat Outcome Meas Review Ulcerative colitis is a chronic condition that requires long-term treatment. The first-line therapy remains 5-ASA, which is available in a variety of different formulations and dosing schedules. Multiple studies have demonstrated that adherence rates to prescribed 5-ASA products is below what would have been expected with significant consequences for important outcomes. Worse disease outcomes, higher medical costs, and even potentially higher rates of colorectal cancer have been associated with nonadherence. Nonadherence is multifactorial, fluid in nature over time, and dependent on disease activity level. Interventions to improve adherence rates have to be individualized. With the advent of simpler dosing regimens it was assumed that adherence rates would improve, but this has not necessarily been the case. Despite our current knowledge about nonadherence, it remains difficult to manage in the long term. Dove Medical Press 2010-06-15 /pmc/articles/PMC3417898/ /pubmed/22915953 Text en © 2010 Bernick and Kane, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Bernick, Steven J
Kane, Sunanda
Optimizing use of 5-ASA in the treatment of ulcerative colitis: Focus on patient compliance and adherence
title Optimizing use of 5-ASA in the treatment of ulcerative colitis: Focus on patient compliance and adherence
title_full Optimizing use of 5-ASA in the treatment of ulcerative colitis: Focus on patient compliance and adherence
title_fullStr Optimizing use of 5-ASA in the treatment of ulcerative colitis: Focus on patient compliance and adherence
title_full_unstemmed Optimizing use of 5-ASA in the treatment of ulcerative colitis: Focus on patient compliance and adherence
title_short Optimizing use of 5-ASA in the treatment of ulcerative colitis: Focus on patient compliance and adherence
title_sort optimizing use of 5-asa in the treatment of ulcerative colitis: focus on patient compliance and adherence
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417898/
https://www.ncbi.nlm.nih.gov/pubmed/22915953
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