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Pain and efficacy of local anesthetics for central venous access

PURPOSE: To compare pain during injection and efficacy of analgesia of local anesthetics during central venous line placement. METHODS: Sixty-two patients were studied in a randomized, double-blinded prospective fashion. Patients received 1% lidocaine (L), buffered 1% lidocaine (LB), or 2% chloropro...

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Autores principales: Culp, William C, Yousaf, Mohammed, Lowry, Benjamin, McCowan, Timothy C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417938/
https://www.ncbi.nlm.nih.gov/pubmed/22915859
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author Culp, William C
Yousaf, Mohammed
Lowry, Benjamin
McCowan, Timothy C
Culp, William C
author_facet Culp, William C
Yousaf, Mohammed
Lowry, Benjamin
McCowan, Timothy C
Culp, William C
author_sort Culp, William C
collection PubMed
description PURPOSE: To compare pain during injection and efficacy of analgesia of local anesthetics during central venous line placement. METHODS: Sixty-two patients were studied in a randomized, double-blinded prospective fashion. Patients received 1% lidocaine (L), buffered 1% lidocaine (LB), or 2% chloroprocaine (CP) injected around the internal jugular vein for procedural analgesia for central venous access. Patients reported pain via a standard linear visual analog scale, with 0 representing no pain and 10 being the worst pain imaginable. RESULTS: Overall patient perception of pain was better with CP and L than LB with mean scores of CP 2.4, L 2.6, LB 4.2. Pain with injection mean scores were CP 2.1, L 2.5, LB 3.2. Pain with catheter placement scores were CP 2.5, L 1.7, LB 3.4. Operator assessment of overall pain values were CP 1.9, L 2.2, LB 3.4. LB consistently scored the worst, though compared with CP, this only reached statistical significance in overall patient pain and pain at catheter insertion compared with L. CONCLUSION: Though chloroprocaine scored better than lidocaine in 3 of 4 parameters, this trend did not achieve statistical significance. Adding sodium bicarbonate to lidocaine isn’t justified in routine practice, nor is routine replacement of lidocaine with chloroprocaine.
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spelling pubmed-34179382012-08-22 Pain and efficacy of local anesthetics for central venous access Culp, William C Yousaf, Mohammed Lowry, Benjamin McCowan, Timothy C Culp, William C Local Reg Anesth Original Research PURPOSE: To compare pain during injection and efficacy of analgesia of local anesthetics during central venous line placement. METHODS: Sixty-two patients were studied in a randomized, double-blinded prospective fashion. Patients received 1% lidocaine (L), buffered 1% lidocaine (LB), or 2% chloroprocaine (CP) injected around the internal jugular vein for procedural analgesia for central venous access. Patients reported pain via a standard linear visual analog scale, with 0 representing no pain and 10 being the worst pain imaginable. RESULTS: Overall patient perception of pain was better with CP and L than LB with mean scores of CP 2.4, L 2.6, LB 4.2. Pain with injection mean scores were CP 2.1, L 2.5, LB 3.2. Pain with catheter placement scores were CP 2.5, L 1.7, LB 3.4. Operator assessment of overall pain values were CP 1.9, L 2.2, LB 3.4. LB consistently scored the worst, though compared with CP, this only reached statistical significance in overall patient pain and pain at catheter insertion compared with L. CONCLUSION: Though chloroprocaine scored better than lidocaine in 3 of 4 parameters, this trend did not achieve statistical significance. Adding sodium bicarbonate to lidocaine isn’t justified in routine practice, nor is routine replacement of lidocaine with chloroprocaine. Dove Medical Press 2008-11-09 /pmc/articles/PMC3417938/ /pubmed/22915859 Text en © 2008 Culp et al, publisher and licensee Dove Medical Press Ltd This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Culp, William C
Yousaf, Mohammed
Lowry, Benjamin
McCowan, Timothy C
Culp, William C
Pain and efficacy of local anesthetics for central venous access
title Pain and efficacy of local anesthetics for central venous access
title_full Pain and efficacy of local anesthetics for central venous access
title_fullStr Pain and efficacy of local anesthetics for central venous access
title_full_unstemmed Pain and efficacy of local anesthetics for central venous access
title_short Pain and efficacy of local anesthetics for central venous access
title_sort pain and efficacy of local anesthetics for central venous access
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417938/
https://www.ncbi.nlm.nih.gov/pubmed/22915859
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