Application of nanogel systems in the administration of local anesthetics

Nanogels are robust nanoparticles that could be used to deliver active drug compounds in controlled drug delivery applications. This review discusses the design, synthesis, loading, and release of local anesthetics using polymeric nanoparticles produced via various types of polymerization techniques...

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Detalles Bibliográficos
Autores principales: Tan, Jeremy PK, Tan, Maureen BH, Tam, Michael KC
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417954/
https://www.ncbi.nlm.nih.gov/pubmed/22915875
http://dx.doi.org/10.2147/LRA.S7977
Descripción
Sumario:Nanogels are robust nanoparticles that could be used to deliver active drug compounds in controlled drug delivery applications. This review discusses the design, synthesis, loading, and release of local anesthetics using polymeric nanoparticles produced via various types of polymerization techniques. The strategy of using layer-by-layer approach to control the burst release of procaine hydrochloride (PrHy; a local anesthetic drug of the amino ester group) is described and discussed.

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