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Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study

BACKGROUND: The impact of serum uric acid (SUA) on arteries of hypertensive subjects remains to be fully established. This study investigated the relationship between SUA and carotid structural and hemodynamic parameters in hypertensive men and women. METHODS: Three hundred and thirty eight patients...

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Autores principales: Cipolli, José Alexandre Addeo, Ferreira-Sae, Maria Carolina, Martins, Rafael Prado, Pio-Magalhães, José Alexandre, Bellinazzi, Vera Regina, Matos-Souza, José Roberto, Junior, Wilson Nadruz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418193/
https://www.ncbi.nlm.nih.gov/pubmed/22800461
http://dx.doi.org/10.1186/1471-2261-12-52
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author Cipolli, José Alexandre Addeo
Ferreira-Sae, Maria Carolina
Martins, Rafael Prado
Pio-Magalhães, José Alexandre
Bellinazzi, Vera Regina
Matos-Souza, José Roberto
Junior, Wilson Nadruz
author_facet Cipolli, José Alexandre Addeo
Ferreira-Sae, Maria Carolina
Martins, Rafael Prado
Pio-Magalhães, José Alexandre
Bellinazzi, Vera Regina
Matos-Souza, José Roberto
Junior, Wilson Nadruz
author_sort Cipolli, José Alexandre Addeo
collection PubMed
description BACKGROUND: The impact of serum uric acid (SUA) on arteries of hypertensive subjects remains to be fully established. This study investigated the relationship between SUA and carotid structural and hemodynamic parameters in hypertensive men and women. METHODS: Three hundred and thirty eight patients (207 women and 131 men) were cross-sectionally evaluated by clinical, laboratory, hemodynamic and carotid ultrasound analysis. Common carotid diameters, circumferential wall tensions, Young’s Elastic Modulus, Stiffness Index, Arterial Compliance and intima-media thickness (IMT) were determined. Internal carotid artery resistive index (ICRI), a hemodynamic measure that reflects local vascular impedance and microangiopathy, was also assessed. RESULTS: Univariate analysis showed no significant correlation of SUA with carotid diameters, elasticity/stiffness indexes, IMT and circumferential wall tensions in both genders. Conversely, SUA correlated with ICRI (r = 0.34; p < 0.001) in women, but not in men, and hyperuricemic women presented higher ICRI than normouricemic ones (0.684 ± 0.007 vs. 0.649 ± 0.004; p < 0.001). Stepwise and logistic regression analyses adjusted for potential confounding factors showed that ICRI was independently associated with SUA and hyperuricemia in women. CONCLUSIONS: This study demonstrated that SUA was associated with ICRI in hypertensive women, suggesting that there might gender-related differences in the relationship between SUA and vascular damage in subjects with systemic hypertension.
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spelling pubmed-34181932012-08-14 Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study Cipolli, José Alexandre Addeo Ferreira-Sae, Maria Carolina Martins, Rafael Prado Pio-Magalhães, José Alexandre Bellinazzi, Vera Regina Matos-Souza, José Roberto Junior, Wilson Nadruz BMC Cardiovasc Disord Research Article BACKGROUND: The impact of serum uric acid (SUA) on arteries of hypertensive subjects remains to be fully established. This study investigated the relationship between SUA and carotid structural and hemodynamic parameters in hypertensive men and women. METHODS: Three hundred and thirty eight patients (207 women and 131 men) were cross-sectionally evaluated by clinical, laboratory, hemodynamic and carotid ultrasound analysis. Common carotid diameters, circumferential wall tensions, Young’s Elastic Modulus, Stiffness Index, Arterial Compliance and intima-media thickness (IMT) were determined. Internal carotid artery resistive index (ICRI), a hemodynamic measure that reflects local vascular impedance and microangiopathy, was also assessed. RESULTS: Univariate analysis showed no significant correlation of SUA with carotid diameters, elasticity/stiffness indexes, IMT and circumferential wall tensions in both genders. Conversely, SUA correlated with ICRI (r = 0.34; p < 0.001) in women, but not in men, and hyperuricemic women presented higher ICRI than normouricemic ones (0.684 ± 0.007 vs. 0.649 ± 0.004; p < 0.001). Stepwise and logistic regression analyses adjusted for potential confounding factors showed that ICRI was independently associated with SUA and hyperuricemia in women. CONCLUSIONS: This study demonstrated that SUA was associated with ICRI in hypertensive women, suggesting that there might gender-related differences in the relationship between SUA and vascular damage in subjects with systemic hypertension. BioMed Central 2012-07-16 /pmc/articles/PMC3418193/ /pubmed/22800461 http://dx.doi.org/10.1186/1471-2261-12-52 Text en Copyright ©2012 Cipolli et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cipolli, José Alexandre Addeo
Ferreira-Sae, Maria Carolina
Martins, Rafael Prado
Pio-Magalhães, José Alexandre
Bellinazzi, Vera Regina
Matos-Souza, José Roberto
Junior, Wilson Nadruz
Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study
title Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study
title_full Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study
title_fullStr Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study
title_full_unstemmed Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study
title_short Relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study
title_sort relationship between serum uric acid and internal carotid resistive index in hypertensive women: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418193/
https://www.ncbi.nlm.nih.gov/pubmed/22800461
http://dx.doi.org/10.1186/1471-2261-12-52
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