Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity

Retinoic acid inducible gene I (RIG-I)-like receptors (RLRs) function as cytoplasmic sensors for viral RNA to initiate antiviral responses including type I interferon (IFN) production. It has been unclear how RIG-I encounters and senses viral RNA. To address this issue, we examined intracellular loc...

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Detalles Bibliográficos
Autores principales: Onomoto, Koji, Jogi, Michihiko, Yoo, Ji-Seung, Narita, Ryo, Morimoto, Shiho, Takemura, Azumi, Sambhara, Suryaprakash, Kawaguchi, Atushi, Osari, Suguru, Nagata, Kyosuke, Matsumiya, Tomoh, Namiki, Hideo, Yoneyama, Mitsutoshi, Fujita, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418241/
https://www.ncbi.nlm.nih.gov/pubmed/22912779
http://dx.doi.org/10.1371/journal.pone.0043031

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