Stem Cell Microvesicles Transfer Cystinosin to Human Cystinotic Cells and Reduce Cystine Accumulation In Vitro

Cystinosis is a rare disease caused by homozygous mutations of the CTNS gene, encoding a cystine efflux channel in the lysosomal membrane. In Ctns knockout mice, the pathologic intralysosomal accumulation of cystine that drives progressive organ damage can be reversed by infusion of wildtype bone ma...

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Detalles Bibliográficos
Autores principales: Iglesias, Diana M., El-Kares, Reyhan, Taranta, Anna, Bellomo, Francesco, Emma, Francesco, Besouw, Martine, Levtchenko, Elena, Toelen, Jaan, van den Heuvel, Lambertus, Chu, LeeLee, Zhao, Jing, Young, Yoon Kow, Eliopoulos, Nicoletta, Goodyer, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418268/
https://www.ncbi.nlm.nih.gov/pubmed/22912749
http://dx.doi.org/10.1371/journal.pone.0042840

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