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Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective

Betel nut (BN), betel quid (BQ) and products derived from them are widely used as a socially endorsed masticatory product. The addictive nature of BN/BQ has resulted in its widespread usage making it the fourth most abused substance by humans. Progressively, several additives, including chewing toba...

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Autores principales: Sharan, Rajeshwar N., Mehrotra, Ravi, Choudhury, Yashmin, Asotra, Kamlesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418282/
https://www.ncbi.nlm.nih.gov/pubmed/22912735
http://dx.doi.org/10.1371/journal.pone.0042759
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author Sharan, Rajeshwar N.
Mehrotra, Ravi
Choudhury, Yashmin
Asotra, Kamlesh
author_facet Sharan, Rajeshwar N.
Mehrotra, Ravi
Choudhury, Yashmin
Asotra, Kamlesh
author_sort Sharan, Rajeshwar N.
collection PubMed
description Betel nut (BN), betel quid (BQ) and products derived from them are widely used as a socially endorsed masticatory product. The addictive nature of BN/BQ has resulted in its widespread usage making it the fourth most abused substance by humans. Progressively, several additives, including chewing tobacco, got added to simple BN preparations. This addictive practice has been shown to have strong etiological correlation with human susceptibility to cancer, particularly oral and oropharyngeal cancers. The PUBMED database was searched to retrieve all relevant published studies in English on BN and BQ, and its association with oral and oropharyngeal cancers. Only complete studies directly dealing with BN/BQ induced carcinogenesis using statistically valid and acceptable sample size were analyzed. Additional relevant information available from other sources was also considered. This systematic review attempts to put in perspective the consequences of this widespread habit of BN/BQ mastication, practiced by approximately 10% of the world population, on oral cancer with a clinical perspective. BN/BQ mastication seems to be significantly associated with susceptibility to oral and oropharyngeal cancers. Addition of tobacco to BN has been found to only marginally increase the cancer risk. Despite the widespread usage of BN/BQ and its strong association with human susceptibility to cancer, no serious strategy seems to exist to control this habit. The review, therefore, also looks at various preventive efforts being made by governments and highlights the multifaceted intervention strategies required to mitigate and/or control the habit of BN/BQ mastication.
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spelling pubmed-34182822012-08-21 Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective Sharan, Rajeshwar N. Mehrotra, Ravi Choudhury, Yashmin Asotra, Kamlesh PLoS One Research Article Betel nut (BN), betel quid (BQ) and products derived from them are widely used as a socially endorsed masticatory product. The addictive nature of BN/BQ has resulted in its widespread usage making it the fourth most abused substance by humans. Progressively, several additives, including chewing tobacco, got added to simple BN preparations. This addictive practice has been shown to have strong etiological correlation with human susceptibility to cancer, particularly oral and oropharyngeal cancers. The PUBMED database was searched to retrieve all relevant published studies in English on BN and BQ, and its association with oral and oropharyngeal cancers. Only complete studies directly dealing with BN/BQ induced carcinogenesis using statistically valid and acceptable sample size were analyzed. Additional relevant information available from other sources was also considered. This systematic review attempts to put in perspective the consequences of this widespread habit of BN/BQ mastication, practiced by approximately 10% of the world population, on oral cancer with a clinical perspective. BN/BQ mastication seems to be significantly associated with susceptibility to oral and oropharyngeal cancers. Addition of tobacco to BN has been found to only marginally increase the cancer risk. Despite the widespread usage of BN/BQ and its strong association with human susceptibility to cancer, no serious strategy seems to exist to control this habit. The review, therefore, also looks at various preventive efforts being made by governments and highlights the multifaceted intervention strategies required to mitigate and/or control the habit of BN/BQ mastication. Public Library of Science 2012-08-13 /pmc/articles/PMC3418282/ /pubmed/22912735 http://dx.doi.org/10.1371/journal.pone.0042759 Text en © 2012 Sharan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Sharan, Rajeshwar N.
Mehrotra, Ravi
Choudhury, Yashmin
Asotra, Kamlesh
Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective
title Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective
title_full Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective
title_fullStr Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective
title_full_unstemmed Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective
title_short Association of Betel Nut with Carcinogenesis: Revisit with a Clinical Perspective
title_sort association of betel nut with carcinogenesis: revisit with a clinical perspective
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418282/
https://www.ncbi.nlm.nih.gov/pubmed/22912735
http://dx.doi.org/10.1371/journal.pone.0042759
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