Epi4K: Gene discovery in 4,000 genomes

A major challenge in epilepsy research is to unravel the complex genetic mechanisms underlying both common and rare forms of epilepsy, as well as the genetic determinants of response to treatment. To accelerate progress in this area, the National Institute of Neurological Disorders and Stroke (NINDS...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Special Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418423/
https://www.ncbi.nlm.nih.gov/pubmed/22642626
http://dx.doi.org/10.1111/j.1528-1167.2012.03511.x
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description A major challenge in epilepsy research is to unravel the complex genetic mechanisms underlying both common and rare forms of epilepsy, as well as the genetic determinants of response to treatment. To accelerate progress in this area, the National Institute of Neurological Disorders and Stroke (NINDS) recently offered funding for the creation of a “Center without Walls” to focus on the genetics of human epilepsy. This article describes Epi4K, the collaborative study supported through this grant mechanism and having the aim of analyzing the genomes of a minimum 4,000 subjects with highly selected and well-characterized epilepsy.
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spelling pubmed-34184232012-09-17 Epi4K: Gene discovery in 4,000 genomes Epilepsia Special Report A major challenge in epilepsy research is to unravel the complex genetic mechanisms underlying both common and rare forms of epilepsy, as well as the genetic determinants of response to treatment. To accelerate progress in this area, the National Institute of Neurological Disorders and Stroke (NINDS) recently offered funding for the creation of a “Center without Walls” to focus on the genetics of human epilepsy. This article describes Epi4K, the collaborative study supported through this grant mechanism and having the aim of analyzing the genomes of a minimum 4,000 subjects with highly selected and well-characterized epilepsy. Blackwell Publishing Ltd 2012-08 2012-05-29 /pmc/articles/PMC3418423/ /pubmed/22642626 http://dx.doi.org/10.1111/j.1528-1167.2012.03511.x Text en Wiley Periodicals, Inc. © 2012 International League Against Epilepsy http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Special Report
Epi4K: Gene discovery in 4,000 genomes
title Epi4K: Gene discovery in 4,000 genomes
title_full Epi4K: Gene discovery in 4,000 genomes
title_fullStr Epi4K: Gene discovery in 4,000 genomes
title_full_unstemmed Epi4K: Gene discovery in 4,000 genomes
title_short Epi4K: Gene discovery in 4,000 genomes
title_sort epi4k: gene discovery in 4,000 genomes
topic Special Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418423/
https://www.ncbi.nlm.nih.gov/pubmed/22642626
http://dx.doi.org/10.1111/j.1528-1167.2012.03511.x
work_keys_str_mv AT epi4kgenediscoveryin4000genomes

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