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Liver expression quantitative trait loci: a foundation for pharmacogenomic research

Expression quantitative trait loci (eQTL) analysis can provide insights into the genetic regulation of gene expression at a genomic level and this information is proving extremely useful in many different areas of research. As a consequence of the role of the liver in drug metabolism and disposition...

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Detalles Bibliográficos
Autores principales: Glubb, Dylan M., Dholakia, Neepa, Innocenti, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418580/
https://www.ncbi.nlm.nih.gov/pubmed/22912647
http://dx.doi.org/10.3389/fgene.2012.00153
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author Glubb, Dylan M.
Dholakia, Neepa
Innocenti, Federico
author_facet Glubb, Dylan M.
Dholakia, Neepa
Innocenti, Federico
author_sort Glubb, Dylan M.
collection PubMed
description Expression quantitative trait loci (eQTL) analysis can provide insights into the genetic regulation of gene expression at a genomic level and this information is proving extremely useful in many different areas of research. As a consequence of the role of the liver in drug metabolism and disposition, the study of eQTLs in primary human liver tissue could provide a foundation for pharmacogenomics. Thus far, four genome-wide eQTL studies have been performed using human livers. Many liver eQTLs have been found to be reproducible and a proportion of these may be specific to the liver. Already these data have been used to interpret and inform clinic genome-wide association studies, providing potential mechanistic evidence for clinical associations and identifying genes which may impact clinical phenotypes. However, the utility of liver eQTL data has not yet been fully explored or realized in pharmacogenomics. As further liver eQTL research is undertaken, the genetic regulation of gene expression will become much better characterized and this knowledge will create a rational basis for the prospective pharmacogenomic study of many drugs.
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spelling pubmed-34185802012-08-21 Liver expression quantitative trait loci: a foundation for pharmacogenomic research Glubb, Dylan M. Dholakia, Neepa Innocenti, Federico Front Genet Pharmacology Expression quantitative trait loci (eQTL) analysis can provide insights into the genetic regulation of gene expression at a genomic level and this information is proving extremely useful in many different areas of research. As a consequence of the role of the liver in drug metabolism and disposition, the study of eQTLs in primary human liver tissue could provide a foundation for pharmacogenomics. Thus far, four genome-wide eQTL studies have been performed using human livers. Many liver eQTLs have been found to be reproducible and a proportion of these may be specific to the liver. Already these data have been used to interpret and inform clinic genome-wide association studies, providing potential mechanistic evidence for clinical associations and identifying genes which may impact clinical phenotypes. However, the utility of liver eQTL data has not yet been fully explored or realized in pharmacogenomics. As further liver eQTL research is undertaken, the genetic regulation of gene expression will become much better characterized and this knowledge will create a rational basis for the prospective pharmacogenomic study of many drugs. Frontiers Media S.A. 2012-08-14 /pmc/articles/PMC3418580/ /pubmed/22912647 http://dx.doi.org/10.3389/fgene.2012.00153 Text en Copyright © 2012 Glubb, Dholakia and Innocenti. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Pharmacology
Glubb, Dylan M.
Dholakia, Neepa
Innocenti, Federico
Liver expression quantitative trait loci: a foundation for pharmacogenomic research
title Liver expression quantitative trait loci: a foundation for pharmacogenomic research
title_full Liver expression quantitative trait loci: a foundation for pharmacogenomic research
title_fullStr Liver expression quantitative trait loci: a foundation for pharmacogenomic research
title_full_unstemmed Liver expression quantitative trait loci: a foundation for pharmacogenomic research
title_short Liver expression quantitative trait loci: a foundation for pharmacogenomic research
title_sort liver expression quantitative trait loci: a foundation for pharmacogenomic research
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418580/
https://www.ncbi.nlm.nih.gov/pubmed/22912647
http://dx.doi.org/10.3389/fgene.2012.00153
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