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Cardiovascular Autonomic Response to Amlodipine in Primary Hypertension
Sympathetic hyperactivity may be involved in primary hypertension. The purpose of this study was to evaluate both sympathetic and vagal activity responses in patients receiving amlodipine as antihypertensive agent. Patients and Methods. This prospective study included a group of primary hypertensive...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418654/ https://www.ncbi.nlm.nih.gov/pubmed/22919515 http://dx.doi.org/10.5402/2012/832183 |
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author | Radjab, Youssouf Aboudrar, Souad Milouk, Fatima Zahra Rkain, Hanan EL Bakkali, Mustapha Dakka, Taoufiq Coghlan, Leslie Benjelloun, Halima |
author_facet | Radjab, Youssouf Aboudrar, Souad Milouk, Fatima Zahra Rkain, Hanan EL Bakkali, Mustapha Dakka, Taoufiq Coghlan, Leslie Benjelloun, Halima |
author_sort | Radjab, Youssouf |
collection | PubMed |
description | Sympathetic hyperactivity may be involved in primary hypertension. The purpose of this study was to evaluate both sympathetic and vagal activity responses in patients receiving amlodipine as antihypertensive agent. Patients and Methods. This prospective study included a group of primary hypertensive patients (N = 32, mean age 54.6 ± 7.6 years). The cardiovascular autonomic tests performed in this group, before and after 3 months of daily oral administration of amlodipine, included deep breathing, hand-grip, and mental stress tests. Statistical analysis was done using the Student's t-test. Results. Cardiovascular autonomic reflexes responses before and after 3 months of amlodipine oral administration were as follows: the mental stress test stimulation method produced a central alpha adrenergic response of 23.9 ± 8.7% versus 11.2 ± 2.0% (P < 0.05), a central beta sympathetic response of 16.7 ± 9.2% versus 10.4 ± 1.3% (P < 0.05), a blood pressure increase in response to hand grip test of 20.5 ± 7.3% versus 10.7 ± 2.4% (P < 0.05), vagal response to deep breathing test was 21.2 ± 6.5% versus 30.8 ± 2.9%, (P < 0.05). Conclusion. The results attest that amlodipine may have an anti-sympathetic effect. |
format | Online Article Text |
id | pubmed-3418654 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-34186542012-08-23 Cardiovascular Autonomic Response to Amlodipine in Primary Hypertension Radjab, Youssouf Aboudrar, Souad Milouk, Fatima Zahra Rkain, Hanan EL Bakkali, Mustapha Dakka, Taoufiq Coghlan, Leslie Benjelloun, Halima ISRN Cardiol Research Article Sympathetic hyperactivity may be involved in primary hypertension. The purpose of this study was to evaluate both sympathetic and vagal activity responses in patients receiving amlodipine as antihypertensive agent. Patients and Methods. This prospective study included a group of primary hypertensive patients (N = 32, mean age 54.6 ± 7.6 years). The cardiovascular autonomic tests performed in this group, before and after 3 months of daily oral administration of amlodipine, included deep breathing, hand-grip, and mental stress tests. Statistical analysis was done using the Student's t-test. Results. Cardiovascular autonomic reflexes responses before and after 3 months of amlodipine oral administration were as follows: the mental stress test stimulation method produced a central alpha adrenergic response of 23.9 ± 8.7% versus 11.2 ± 2.0% (P < 0.05), a central beta sympathetic response of 16.7 ± 9.2% versus 10.4 ± 1.3% (P < 0.05), a blood pressure increase in response to hand grip test of 20.5 ± 7.3% versus 10.7 ± 2.4% (P < 0.05), vagal response to deep breathing test was 21.2 ± 6.5% versus 30.8 ± 2.9%, (P < 0.05). Conclusion. The results attest that amlodipine may have an anti-sympathetic effect. International Scholarly Research Network 2012-06-25 /pmc/articles/PMC3418654/ /pubmed/22919515 http://dx.doi.org/10.5402/2012/832183 Text en Copyright © 2012 Youssouf Radjab et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Radjab, Youssouf Aboudrar, Souad Milouk, Fatima Zahra Rkain, Hanan EL Bakkali, Mustapha Dakka, Taoufiq Coghlan, Leslie Benjelloun, Halima Cardiovascular Autonomic Response to Amlodipine in Primary Hypertension |
title | Cardiovascular Autonomic Response to Amlodipine in Primary Hypertension |
title_full | Cardiovascular Autonomic Response to Amlodipine in Primary Hypertension |
title_fullStr | Cardiovascular Autonomic Response to Amlodipine in Primary Hypertension |
title_full_unstemmed | Cardiovascular Autonomic Response to Amlodipine in Primary Hypertension |
title_short | Cardiovascular Autonomic Response to Amlodipine in Primary Hypertension |
title_sort | cardiovascular autonomic response to amlodipine in primary hypertension |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418654/ https://www.ncbi.nlm.nih.gov/pubmed/22919515 http://dx.doi.org/10.5402/2012/832183 |
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