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The strategy for enhancing temozolomide against malignant glioma

A combined therapy of the alkylating agent temozolomide (TMZ) and radiotherapy is standard treatment, and it improves the survival of patients with newly diagnosed glioblastoma (GBM). The DNA repair enzyme O(6)-methylguanine-DNA methyltransferase (MGMT) removes the most cytotoxic lesions generated b...

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Detalles Bibliográficos
Autores principales:	Nakada, Mitsutoshi, Furuta, Takuya, Hayashi, Yutaka, Minamoto, Toshinari, Hamada, Jun-ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2012
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418701/ https://www.ncbi.nlm.nih.gov/pubmed/22912934 http://dx.doi.org/10.3389/fonc.2012.00098

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