Cargando…

Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function

OBJECTIVE: Both decreased glomerular filtration rate (GFR) and arterial stiffness were considered as risk factors for atherosclerosis. Previous studies have suggested the association between central arterial stiffness and the degree of GFR loss. Whether decreased GFR contributes to peripheral artery...

Descripción completa

Detalles Bibliográficos
Autores principales: Bian, Su-Yan, Guo, Hong-Yang, Ye, Ping, Luo, Lei-Ming, Wu, Hong-Mei, Xiao, Wen-Kai, Qi, Li-Ping, Yu, He-Peng, Duan, Liu-Fa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418906/
https://www.ncbi.nlm.nih.gov/pubmed/22916063
http://dx.doi.org/10.3724/SP.J.1263.2012.03051
_version_ 1782240669157294080
author Bian, Su-Yan
Guo, Hong-Yang
Ye, Ping
Luo, Lei-Ming
Wu, Hong-Mei
Xiao, Wen-Kai
Qi, Li-Ping
Yu, He-Peng
Duan, Liu-Fa
author_facet Bian, Su-Yan
Guo, Hong-Yang
Ye, Ping
Luo, Lei-Ming
Wu, Hong-Mei
Xiao, Wen-Kai
Qi, Li-Ping
Yu, He-Peng
Duan, Liu-Fa
author_sort Bian, Su-Yan
collection PubMed
description OBJECTIVE: Both decreased glomerular filtration rate (GFR) and arterial stiffness were considered as risk factors for atherosclerosis. Previous studies have suggested the association between central arterial stiffness and the degree of GFR loss. Whether decreased GFR contributes to peripheral artery stiffness remains controversial. Moreover, data analyzed from a cohort of Chinese women are rare. Our aim was to explore the relationship between GFR and regional arterial stiffness in Chinese women. METHODS: In this cross-sectional study, we randomly recruited 1131 adult women residents with GFR ≥ 60 mL/min per 1.73 m(2) estimated by the Chinese Modification of Diet in Renal Disease equation from three large communities. Central and peripheral arterial stiffness were estimated simultaneously by measuring carotid-femoral pulse wave velocity (PWVcf) and carotid-radial PWV (PWVcr) using a validated automatic device. Augmentation Index at heart rate 75 beats/minutes (AIx-75) was measured by pulse wave analysis as a composite parameter reflecting both large and distal arterial properties. RESULTS: The mean estimated GFR (eGFR) of the study group was 100.05 ± 23.26 mL/minute per 1.73 m(2). Subjects were grouped by tertiles of eGFR level. PWVcf and AIx-75 increased ongoing from the top to the bottom eGFR tertile, while the values of PWVcr were comparable. Both univariate Pearson correlations and multiple stepwise regression analyses showed that eGFR significantly correlated to PWVcf, but not to PWVcr and AIx-75. CONCLUSIONS: In Chinese women with normal to mildly impaired renal function, decreased eGFR affected carotid-to-femoral rather than carotid-to-radial stiffening. This provides rational to conduct future prospective studies to investigate predictors of atherosclerosis in this population.
format Online
Article
Text
id pubmed-3418906
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Science Press
record_format MEDLINE/PubMed
spelling pubmed-34189062012-08-22 Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function Bian, Su-Yan Guo, Hong-Yang Ye, Ping Luo, Lei-Ming Wu, Hong-Mei Xiao, Wen-Kai Qi, Li-Ping Yu, He-Peng Duan, Liu-Fa J Geriatr Cardiol Research Articles OBJECTIVE: Both decreased glomerular filtration rate (GFR) and arterial stiffness were considered as risk factors for atherosclerosis. Previous studies have suggested the association between central arterial stiffness and the degree of GFR loss. Whether decreased GFR contributes to peripheral artery stiffness remains controversial. Moreover, data analyzed from a cohort of Chinese women are rare. Our aim was to explore the relationship between GFR and regional arterial stiffness in Chinese women. METHODS: In this cross-sectional study, we randomly recruited 1131 adult women residents with GFR ≥ 60 mL/min per 1.73 m(2) estimated by the Chinese Modification of Diet in Renal Disease equation from three large communities. Central and peripheral arterial stiffness were estimated simultaneously by measuring carotid-femoral pulse wave velocity (PWVcf) and carotid-radial PWV (PWVcr) using a validated automatic device. Augmentation Index at heart rate 75 beats/minutes (AIx-75) was measured by pulse wave analysis as a composite parameter reflecting both large and distal arterial properties. RESULTS: The mean estimated GFR (eGFR) of the study group was 100.05 ± 23.26 mL/minute per 1.73 m(2). Subjects were grouped by tertiles of eGFR level. PWVcf and AIx-75 increased ongoing from the top to the bottom eGFR tertile, while the values of PWVcr were comparable. Both univariate Pearson correlations and multiple stepwise regression analyses showed that eGFR significantly correlated to PWVcf, but not to PWVcr and AIx-75. CONCLUSIONS: In Chinese women with normal to mildly impaired renal function, decreased eGFR affected carotid-to-femoral rather than carotid-to-radial stiffening. This provides rational to conduct future prospective studies to investigate predictors of atherosclerosis in this population. Science Press 2012-06 /pmc/articles/PMC3418906/ /pubmed/22916063 http://dx.doi.org/10.3724/SP.J.1263.2012.03051 Text en Institute of Geriatric Cardiology http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Research Articles
Bian, Su-Yan
Guo, Hong-Yang
Ye, Ping
Luo, Lei-Ming
Wu, Hong-Mei
Xiao, Wen-Kai
Qi, Li-Ping
Yu, He-Peng
Duan, Liu-Fa
Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function
title Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function
title_full Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function
title_fullStr Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function
title_full_unstemmed Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function
title_short Association of glomerular filtration rate with arterial stiffness in Chinese women with normal to mildly impaired renal function
title_sort association of glomerular filtration rate with arterial stiffness in chinese women with normal to mildly impaired renal function
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418906/
https://www.ncbi.nlm.nih.gov/pubmed/22916063
http://dx.doi.org/10.3724/SP.J.1263.2012.03051
work_keys_str_mv AT biansuyan associationofglomerularfiltrationratewitharterialstiffnessinchinesewomenwithnormaltomildlyimpairedrenalfunction
AT guohongyang associationofglomerularfiltrationratewitharterialstiffnessinchinesewomenwithnormaltomildlyimpairedrenalfunction
AT yeping associationofglomerularfiltrationratewitharterialstiffnessinchinesewomenwithnormaltomildlyimpairedrenalfunction
AT luoleiming associationofglomerularfiltrationratewitharterialstiffnessinchinesewomenwithnormaltomildlyimpairedrenalfunction
AT wuhongmei associationofglomerularfiltrationratewitharterialstiffnessinchinesewomenwithnormaltomildlyimpairedrenalfunction
AT xiaowenkai associationofglomerularfiltrationratewitharterialstiffnessinchinesewomenwithnormaltomildlyimpairedrenalfunction
AT qiliping associationofglomerularfiltrationratewitharterialstiffnessinchinesewomenwithnormaltomildlyimpairedrenalfunction
AT yuhepeng associationofglomerularfiltrationratewitharterialstiffnessinchinesewomenwithnormaltomildlyimpairedrenalfunction
AT duanliufa associationofglomerularfiltrationratewitharterialstiffnessinchinesewomenwithnormaltomildlyimpairedrenalfunction