Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function

We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss c...

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Autores principales: Reeve, James E., Kohl, Michael M., Rodríguez-Moreno, Antonio, Paulsen, Ole, Anderson, Harry L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419105/
https://www.ncbi.nlm.nih.gov/pubmed/22896783
http://dx.doi.org/10.4161/cib.19400
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author Reeve, James E.
Kohl, Michael M.
Rodríguez-Moreno, Antonio
Paulsen, Ole
Anderson, Harry L.
author_facet Reeve, James E.
Kohl, Michael M.
Rodríguez-Moreno, Antonio
Paulsen, Ole
Anderson, Harry L.
author_sort Reeve, James E.
collection PubMed
description We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss considerations regarding the choice of caging molecule, synthesis and the potential uses for caged ion channel blockers in neurophysiology.
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spelling pubmed-34191052012-08-15 Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function Reeve, James E. Kohl, Michael M. Rodríguez-Moreno, Antonio Paulsen, Ole Anderson, Harry L. Commun Integr Biol Short Communication We have previously synthesized a caged form of the use-dependent N-methyl-D-aspartate (NMDA) receptor ion channel blocker MK801 and used intracellular photolysis of this compound to demonstrate the subcellular location of NMDA receptor ion channels involved in synaptic plasticity. Here, we discuss considerations regarding the choice of caging molecule, synthesis and the potential uses for caged ion channel blockers in neurophysiology. Landes Bioscience 2012-05-01 /pmc/articles/PMC3419105/ /pubmed/22896783 http://dx.doi.org/10.4161/cib.19400 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Short Communication
Reeve, James E.
Kohl, Michael M.
Rodríguez-Moreno, Antonio
Paulsen, Ole
Anderson, Harry L.
Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
title Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
title_full Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
title_fullStr Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
title_full_unstemmed Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
title_short Caged intracellular NMDA receptor blockers for the study of subcellular ion channel function
title_sort caged intracellular nmda receptor blockers for the study of subcellular ion channel function
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419105/
https://www.ncbi.nlm.nih.gov/pubmed/22896783
http://dx.doi.org/10.4161/cib.19400
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