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The unexpected role of Drosophila OCRL during cytokinesis
Inositides are intrinsic components of cell membranes that regulate a wide variety of cellular functions. PtdIns(4,5)P(2,) one of the most abundant phosphoinositides, is restricted at the plasma membrane where it regulates numerous functions including cell division. We have recently established that...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419118/ https://www.ncbi.nlm.nih.gov/pubmed/22896796 http://dx.doi.org/10.4161/cib.19914 |
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author | Ben El Kadhi, Khaled Emery, Grégory Carreno, Sebastien |
author_facet | Ben El Kadhi, Khaled Emery, Grégory Carreno, Sebastien |
author_sort | Ben El Kadhi, Khaled |
collection | PubMed |
description | Inositides are intrinsic components of cell membranes that regulate a wide variety of cellular functions. PtdIns(4,5)P(2,) one of the most abundant phosphoinositides, is restricted at the plasma membrane where it regulates numerous functions including cell division. We have recently established that the Drosophila inositol 5-phosphatase, dOCRL, is essential for cytokinesis, the last step of cell division (Ben El Kadhi et al. 2011).(8) We demonstrated that dOCRL is required for the dephosphorylation of PtdIns(4,5)P(2) at the surface of endosomes, resulting in the restriction of this phosphoinositide to the cell cortex during cytokinesis. dOCRL is the Drosophila ortholog of human OCRL1, a PtdIns(4,5)P(2) phosphatase mutated in the X-linked disorder oculocerebrorenal Lowe syndrome. Here, we discuss the relevance of our findings with reference to the role of human OCRL1 in non-pathological and pathological conditions. |
format | Online Article Text |
id | pubmed-3419118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-34191182012-08-15 The unexpected role of Drosophila OCRL during cytokinesis Ben El Kadhi, Khaled Emery, Grégory Carreno, Sebastien Commun Integr Biol Article Addendum Inositides are intrinsic components of cell membranes that regulate a wide variety of cellular functions. PtdIns(4,5)P(2,) one of the most abundant phosphoinositides, is restricted at the plasma membrane where it regulates numerous functions including cell division. We have recently established that the Drosophila inositol 5-phosphatase, dOCRL, is essential for cytokinesis, the last step of cell division (Ben El Kadhi et al. 2011).(8) We demonstrated that dOCRL is required for the dephosphorylation of PtdIns(4,5)P(2) at the surface of endosomes, resulting in the restriction of this phosphoinositide to the cell cortex during cytokinesis. dOCRL is the Drosophila ortholog of human OCRL1, a PtdIns(4,5)P(2) phosphatase mutated in the X-linked disorder oculocerebrorenal Lowe syndrome. Here, we discuss the relevance of our findings with reference to the role of human OCRL1 in non-pathological and pathological conditions. Landes Bioscience 2012-05-01 /pmc/articles/PMC3419118/ /pubmed/22896796 http://dx.doi.org/10.4161/cib.19914 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Article Addendum Ben El Kadhi, Khaled Emery, Grégory Carreno, Sebastien The unexpected role of Drosophila OCRL during cytokinesis |
title | The unexpected role of Drosophila OCRL during cytokinesis |
title_full | The unexpected role of Drosophila OCRL during cytokinesis |
title_fullStr | The unexpected role of Drosophila OCRL during cytokinesis |
title_full_unstemmed | The unexpected role of Drosophila OCRL during cytokinesis |
title_short | The unexpected role of Drosophila OCRL during cytokinesis |
title_sort | unexpected role of drosophila ocrl during cytokinesis |
topic | Article Addendum |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419118/ https://www.ncbi.nlm.nih.gov/pubmed/22896796 http://dx.doi.org/10.4161/cib.19914 |
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