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Myosin I: A new pip(3) effector in chemotaxis and phagocytosis

Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) is a key signaling molecule in chemotaxis, a directed cell migration toward chemoattractants. PtdIns(3,4,5)P(3) is transiently generated by chemotactic stimulation and activates reorganization of the actin cytoskeleton at the leading edge...

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Detalles Bibliográficos
Autores principales: Chen, Chun-Lin, Iijima, Miho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419119/
https://www.ncbi.nlm.nih.gov/pubmed/22896797
http://dx.doi.org/10.4161/cib.19892
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author Chen, Chun-Lin
Iijima, Miho
author_facet Chen, Chun-Lin
Iijima, Miho
author_sort Chen, Chun-Lin
collection PubMed
description Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) is a key signaling molecule in chemotaxis, a directed cell migration toward chemoattractants. PtdIns(3,4,5)P(3) is transiently generated by chemotactic stimulation and activates reorganization of the actin cytoskeleton at the leading edge of migrating cells. In a recent study, we demonstrated that PtdIns(3,4,5)P(3) directly binds to three members of the actin-based motor protein myosin I (myosin ID, IE and IF) in Dictyostelium discoideum and recruits these proteins to the plasma membrane of the leading edge. The PtdIns(3,4,5)P(3)-regulated membrane recruitment of myosin I induced chemoattractant-stimulated actin polymerization and was therefore required for chemotaxis. Similarly, human myosin IF was translocated to the plasma membrane through interactions with PtdIns(3,4,5)P(3) upon chemotactic stimulation in a neutrophil cell line. Interestingly, we also found that the three PtdIns(3,4,5)P(3)-binding myosin I proteins function in phagocytosis, which involves both PtdIns(3,4,5)P(3) signaling and actin cytoskeleton remodeling. Our findings provide an evolutionarily conserved mechanism by which class I myosin transmits PtdIns(3,4,5)P(3) signals to the actin cytoskeleton.
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spelling pubmed-34191192012-08-15 Myosin I: A new pip(3) effector in chemotaxis and phagocytosis Chen, Chun-Lin Iijima, Miho Commun Integr Biol Article Addendum Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) is a key signaling molecule in chemotaxis, a directed cell migration toward chemoattractants. PtdIns(3,4,5)P(3) is transiently generated by chemotactic stimulation and activates reorganization of the actin cytoskeleton at the leading edge of migrating cells. In a recent study, we demonstrated that PtdIns(3,4,5)P(3) directly binds to three members of the actin-based motor protein myosin I (myosin ID, IE and IF) in Dictyostelium discoideum and recruits these proteins to the plasma membrane of the leading edge. The PtdIns(3,4,5)P(3)-regulated membrane recruitment of myosin I induced chemoattractant-stimulated actin polymerization and was therefore required for chemotaxis. Similarly, human myosin IF was translocated to the plasma membrane through interactions with PtdIns(3,4,5)P(3) upon chemotactic stimulation in a neutrophil cell line. Interestingly, we also found that the three PtdIns(3,4,5)P(3)-binding myosin I proteins function in phagocytosis, which involves both PtdIns(3,4,5)P(3) signaling and actin cytoskeleton remodeling. Our findings provide an evolutionarily conserved mechanism by which class I myosin transmits PtdIns(3,4,5)P(3) signals to the actin cytoskeleton. Landes Bioscience 2012-05-01 /pmc/articles/PMC3419119/ /pubmed/22896797 http://dx.doi.org/10.4161/cib.19892 Text en Copyright © 2012 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Article Addendum
Chen, Chun-Lin
Iijima, Miho
Myosin I: A new pip(3) effector in chemotaxis and phagocytosis
title Myosin I: A new pip(3) effector in chemotaxis and phagocytosis
title_full Myosin I: A new pip(3) effector in chemotaxis and phagocytosis
title_fullStr Myosin I: A new pip(3) effector in chemotaxis and phagocytosis
title_full_unstemmed Myosin I: A new pip(3) effector in chemotaxis and phagocytosis
title_short Myosin I: A new pip(3) effector in chemotaxis and phagocytosis
title_sort myosin i: a new pip(3) effector in chemotaxis and phagocytosis
topic Article Addendum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419119/
https://www.ncbi.nlm.nih.gov/pubmed/22896797
http://dx.doi.org/10.4161/cib.19892
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AT iijimamiho myosinianewpip3effectorinchemotaxisandphagocytosis