RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma

Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In th...

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Autores principales: Weinstein, Shiri, Emmanuel, Rafi, Jacobi, Ashley M., Abraham, Avigdor, Behlke, Mark A., Sprague, Andrew G., Novobrantseva, Tatiana I., Nagler, Arnon, Peer, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419170/
https://www.ncbi.nlm.nih.gov/pubmed/22905260
http://dx.doi.org/10.1371/journal.pone.0043343
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author Weinstein, Shiri
Emmanuel, Rafi
Jacobi, Ashley M.
Abraham, Avigdor
Behlke, Mark A.
Sprague, Andrew G.
Novobrantseva, Tatiana I.
Nagler, Arnon
Peer, Dan
author_facet Weinstein, Shiri
Emmanuel, Rafi
Jacobi, Ashley M.
Abraham, Avigdor
Behlke, Mark A.
Sprague, Andrew G.
Novobrantseva, Tatiana I.
Nagler, Arnon
Peer, Dan
author_sort Weinstein, Shiri
collection PubMed
description Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In this study, we used RNA interference strategies to examine whether cyclin D1 might serve as a therapeutic target for mantle cell lymphoma. Knocking down cyclin D1 resulted in significant growth retardation, cell cycle arrest, and most importantly, induction of apoptosis. These results mark cyclin D1 as a target for mantle cell lymphoma and emphasize the therapeutic potential hidden in its silencing.
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spelling pubmed-34191702012-08-19 RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma Weinstein, Shiri Emmanuel, Rafi Jacobi, Ashley M. Abraham, Avigdor Behlke, Mark A. Sprague, Andrew G. Novobrantseva, Tatiana I. Nagler, Arnon Peer, Dan PLoS One Research Article Mantle cell lymphoma is characterized by a genetic translocation results in aberrant overexpression of the CCND1 gene, which encodes cyclin D1. This protein functions as a regulator of the cell cycle progression, hence is considered to play an important role in the pathogenesis of the disease. In this study, we used RNA interference strategies to examine whether cyclin D1 might serve as a therapeutic target for mantle cell lymphoma. Knocking down cyclin D1 resulted in significant growth retardation, cell cycle arrest, and most importantly, induction of apoptosis. These results mark cyclin D1 as a target for mantle cell lymphoma and emphasize the therapeutic potential hidden in its silencing. Public Library of Science 2012-08-14 /pmc/articles/PMC3419170/ /pubmed/22905260 http://dx.doi.org/10.1371/journal.pone.0043343 Text en © 2012 Weinstein et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Weinstein, Shiri
Emmanuel, Rafi
Jacobi, Ashley M.
Abraham, Avigdor
Behlke, Mark A.
Sprague, Andrew G.
Novobrantseva, Tatiana I.
Nagler, Arnon
Peer, Dan
RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma
title RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma
title_full RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma
title_fullStr RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma
title_full_unstemmed RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma
title_short RNA Inhibition Highlights Cyclin D1 as a Potential Therapeutic Target for Mantle Cell Lymphoma
title_sort rna inhibition highlights cyclin d1 as a potential therapeutic target for mantle cell lymphoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419170/
https://www.ncbi.nlm.nih.gov/pubmed/22905260
http://dx.doi.org/10.1371/journal.pone.0043343
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